Objective: To analyze the efficacy of conventional dose of methylprednisolone sodium succinate injection combined with inhaled corticosteroids (ICS) in the treatment of children with refractory Mycoplasma pneumoniae pneumonia (RMPP)

so as to provide reference for rational drug use in clinic. Methods: Retrospective study method was used

67 children from 2 to 14 years who were diagnosed as RMPP and treated in the respiratory department of our hospital from 2017 to 2018 were recruited. All children were routinely treated with antipyretic

oxygen absorption

anti-infection

cough relieving

expectoration and glucocorticoid. Children treated with glucocorticoid who were given intravenously conventional dose of methylprednisolone sodium succinate injection were extracted into the monotherapy group. Children treated with intravenous administration of conventional dose of methylprednisolone sodium succinate injection combined with ICS atomization inhalation were included into the combined treatment group. Disappearance time of fever

cough and lung rale

fiberoptic bronchoscopy performance in children with radiographic findings of pulmonary consolidation

atelectasis or localized emphysema

changes of pulmonary imaging and clinical efficacy after 2 weeks of treatment

adverse drug reactions

and cases where additional doses or course of methylprednisolone sodium succinate injection were required due to illness in two groups were compared. Results: There was no significant difference in disappearance time of fever between two groups (P>0.05). The disappearance time of cough and lung rale of the combined treatment group was significantly shorter (P<0.05). The recovery of patients with pulmonary consolidation

atelectasis or localized emphysema in the combined treatment group was better than that in the monotherapy group

and the number of cases receiving secondary fiberoptic bronchoscopy were significantly less than those in the monotherapy group (P<0.05). After 2 weeks of treatment

the absorption rate of chest radiograph lung shadow and the total effective rate in the combined treatment group was better than that of monntherapy group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). There were fewer cases of prolonging the treatment course of methylprednisolone sodium succinate injection in the combined treatment group (P<0.05). Conclusion: Intravenous administration of conventional dose of methylprednisolone sodium succinate injection combined with ICS atomization inhalation in the treatment of children with RMPP is effective

safe and controllable

and it is worthy of clinical reference.