Effects of Naloxone Combined with Dexmedetomidine Sedation on S100β Protein and Oxygen-Brain Metabolism in Children with Septic Encephalopathy

Wang Yaqiong; Lu Zhaofeng

doi:10.13407/j.cnki.jpp.1672.108X.2020.12.007

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Effects of Naloxone Combined with Dexmedetomidine Sedation on S100β Protein and Oxygen-Brain Metabolism in Children with Septic Encephalopathy

更新时间：2022-11-03

- Effects of Naloxone Combined with Dexmedetomidine Sedation on S100β Protein and Oxygen-Brain Metabolism in Children with Septic Encephalopathy
- Vol. 26, Issue 12, Pages: 22-25(2020)
- 作者机构：
  
  河南科技大学第一附属医院,河南,洛阳,471000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2020.12.007
  CLC：
- Published：2020，
  
  Published Online：10 December 2020，
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Wang Yaqiong, Lu Zhaofeng. Effects of Naloxone Combined with Dexmedetomidine Sedation on S100β Protein and Oxygen-Brain Metabolism in Children with Septic Encephalopathy. [J]. 26(12):22-25(2020)
DOI：

Wang Yaqiong, Lu Zhaofeng. Effects of Naloxone Combined with Dexmedetomidine Sedation on S100β Protein and Oxygen-Brain Metabolism in Children with Septic Encephalopathy. [J]. 26(12):22-25(2020) DOI： 10.13407/j.cnki.jpp.1672.108X.2020.12.007.

摘要

目的：探讨儿童脓毒症脑病的有效对症支持疗法。方法：选取2018年1月至2019年5月我院ICU收治的脓毒症脑病患儿100例，采用随机数表法分为观察组和对照组各50例。对照组患儿接受纳洛酮治疗，观察组患儿接受纳洛酮联合右美托咪定治疗，均持续治疗7 d。观察两组患儿治疗前（T0）、治疗1 d（T1）、治疗3 d（T2）的S100β蛋白水平、脑氧代谢指标如动脉血氧饱和度（rSO2）、颈内静脉血氧饱和度（SjvO2）、颈内静脉血氧含量差（Da-jvO2）、脑氧代谢率（CERO2）以及治疗前后的危重症系统评分（APACHEⅡ）、Glasgow评分。结果：两组患儿T0时的血清S100β、rSO2、SjvO2、Da-jvO2、CERO2水平比较，差异均无统计学意义（P均>0.05）；观察组T1、T2、T3的S100β、Da-jvO2、CERO2水平低于对照组，rSO2、SjvO2水平高于对照组（P均<0.05）。观察组治疗后APACHEⅡ评分低于对照组，Glasgow评分高于对照组（P均<0.05）。结论：纳洛酮联合右美托咪定能降低儿童脓毒症脑病的S100β蛋白水平，维持脑氧代谢平衡。

Abstract

Objective: To investigate the effective symptomatic support therapy for children with septic encephalopathy. Methods: Totally 100 children with septic encephalopathy admitted into ICU of our hospital from Jan. 2018 to May 2019 were extracted to be divided into the observation group and the control group via the random number table

with 50 cases in each group. The control group received naloxone

while the observation group was given naloxone combined with dexmedetomidine

both groups were treated for 7 d. The levels of S100β protein

cerebral oxygen metabolism indicators such as regional cerebral oxygen saturation (rSO2)

internal jugular venous blood oxygen saturation (SjvO2)

internal jugular venous oxygen content difference (Da-jvO2)

cerebral oxygen metabolism rate (CERO2) and acute physiology before treatment (T0)

after treatment of 1 d (T1)

after treatment of 3 d (T2) and chronic health evaluation Ⅱ (APACHEⅡ)

Glasgow score before and after treatment of two groups were observed. Results: There was no statistically significant difference in serum S100β

rSO2

SjvO2

Da-jvO2 and CERO2 levels at T0 between two groups (P>0.05). The levels of S100β

Da-jvO2 and CERO2 in the observation group at T1

T2 and T3 were lower than those in the control group

and the levels of rSO2 and SjvO2 in the observation group were higher than those in the control group (P<0.05). After treatment

the APACHEⅡ score of the observation group was lower than that of the control group

and the Glasgow score was higher than that of the control group (P<0.05). Conclusion: Naloxone combined with dexmedetomidine can reduce the level of S100β protein in children with septic encephalopathy and maintain the balance of cerebral oxygen metabolism.

关键词

纳洛酮右美托咪定儿童脓毒症脑病S100β蛋白脑氧代谢

Keywords

naloxoneexmedetomidinechildrenseptic encephalopathyS100β proteincerebral oxygen metabolism

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