Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals

Chen Shaoxiu; Du Xiao; Jing Haixia; Zhang Xia; Chang Mingquan

doi:10.13407/j.cnki.jpp.1672.108X.2020.12.001

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Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals

更新时间：2022-11-03

- Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals
- Vol. 26, Issue 12, Pages: 1-3(2020)
- 作者机构：
  
  十堰市太和医院，湖北医药学院附属医院,湖北,十堰,442000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2020.12.001
  CLC：
- Published：2020，
  
  Published Online：10 December 2020，
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Chen Shaoxiu, Du Xiao, Jing Haixia, et al. Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals. [J]. 26(12):1-3(2020)
DOI：

Chen Shaoxiu, Du Xiao, Jing Haixia, et al. Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals. [J]. 26(12):1-3(2020) DOI： 10.13407/j.cnki.jpp.1672.108X.2020.12.001.

摘要

目的：研究氯霉素泼尼松搽剂的抗炎、抗过敏和止痒作用，为临床应用提供参考。方法：利用二甲苯诱导小鼠耳朵肿胀观察其抗炎作用；利用2，4-二硝基氯苯（DNCB）诱导小鼠迟发性过敏反应观察其抗过敏作用；利用4-氨基吡啶(4-AP)诱导小鼠皮肤过敏性瘙痒观察其止痒作用。结果：与模型对照组比较，氯霉素泼尼松搽剂能显著减轻二甲苯所致小鼠耳朵肿胀程度，同时降低DNCB诱导的小鼠过敏反应，并能明显减少4-AP诱导小鼠瘙痒的舔体次数、延长瘙痒潜伏期、缩短瘙痒持续时间。结论：氯霉素泼尼松搽剂具有明显的抗炎、抗过敏和止痒作用。

Abstract

Objective: To study the anti-inflammatory

anti-allergic and anti-pruritic effects of chloramphenicol prednisone liniment in animals

so as to provide reference for clinical application. Methods: Anti-inflammatory effects of chloramphenicol prednisone liniment were observed in mice with xylene-induced ear swelling. Anti-allergic effects of chloramphenicol prednisone liniment were observed in mice with delayed-type hypersensitivity induced by 2

4-dinitrochlorobenzene (DNCB). Anti-pruritus effects of chloramphenicol prednisone liniment were observed in mice with skin allergic itching induced by 4-aminopyridine (4-AP). Results: Compared with the model control group

chloramphenicol prednisone liniment could significantly alleviate xylene-induced ear swelling in mice and reduce DNCB-induced allergic reaction in mice. Chloramphenicol prednisone liniment could reduce the number of carcasses induced by 4-AP in mice

prolong pruritus latency and shorten the duration of pruritus. Conclusion: Chloramphenicol prednisone liniment has significant anti-inflammatory

anti-allergic and anti-pruritus effects.

关键词

氯霉素泼尼松搽剂抗炎抗过敏止痒

Keywords

chloramphenicol prednisone linimentanti-inflammatoryanti-allergicanti-pruritus

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