Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Li Changsong; Li Yunxiang; Li Xiaojing; Sun Canlin; Jiang Lin

doi:10.13407/j.cnki.jpp.1672-108X.2024.02.009

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Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

更新时间：2024-03-04

- Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy
- Vol. 30, Issue 2, Pages: 31-35(2024)
- 作者机构：
  
  江苏省泰州市人民医院,江苏,泰州,225300
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2024.02.009
  CLC：
- Published：2024，
  
  Published Online：10 February 2024，
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Li Changsong, Li Yunxiang, Li Xiaojing, et al. Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy. [J]. 30(2):31-35(2024)
DOI：

Li Changsong, Li Yunxiang, Li Xiaojing, et al. Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy. [J]. 30(2):31-35(2024) DOI： 10.13407/j.cnki.jpp.1672-108X.2024.02.009.

摘要

目的:探讨右美托咪定与氢吗啡酮复合滴鼻在小儿腺样体手术术前母婴分离过程中的麻醉镇静效果。方法:选取我院 2021 年1 月-2022 年8 月择期行腺样体手术患儿60 例

采用随机数表法分为观察组和对照组各30 例

观察组采用1. 5 μg/ kg 右美托咪定复合30 μg/ kg 氢吗啡酮滴鼻术前镇静

对照组采用1. 5 μg/ kg 右美托咪定滴鼻术前镇静。比较两组患儿滴鼻前 (T0)、滴鼻后5 min(T1)、15 min(T2)、25 min(T3)各时间点镇静程度(RASS)评分

母婴分离时(T4)的镇静情绪评分

开放静脉时(T5)的睡眠障碍量表(ESS)评分及各时间点脉搏氧饱和度(SpO2 )和心率(HR)的变化

全麻诱导期扣面罩接受程度评分

苏醒期躁动评分以及术后不良反应发生情况等。结果:T1~T3 时间点RASS 评分、T5 时间点ESS 评分、苏醒期躁动评分

观察组均低于对照组(P<0. 05);T4 时间点镇静情绪评分、诱导期扣面罩接受程度评分

观察组均高于对照组(P<0. 05);惊醒哭闹患儿例数和需辅助麻醉患儿例数

观察组少于对照组(P<0. 05);两组患儿T0~T5 时间点HR、SpO2 水平变化均不显著(P>0. 05);两组患儿不良反应发生率比较差异均无统计学意义(P>0. 05)。结论:右美托咪定复合氢吗啡酮术前滴鼻

安全有效

利于腺样体手术患儿与父母安静分离

不良反应少

值得进一步推广应用。

Abstract

Objective: To probe into the anesthetic and sedative effects of dexmedetomidine combined with hydromorphone nasal drip in sedation of mother-infant separation before adenoidectomy. Methods: From Jan. 2021 to Aug. 2022

60 children undergoing elective adenoidectomy were selected to be divided into the observation group and control group via the random number table method

with 30 cases in each group. The observation group received 1. 5 μg/ kg dexmedetomidine combined with 30 μg/ kg hydromorphone nasal drip before surgery

and the control group was given 1. 5 μg/ kg dexmedetomidine nasal drop before surgery. The Richmond Agitation and Sedation Scale (RASS) scores of two groups were compared before (T0)

5 min after nasal drops (T1)

15 min after nasal drops (T2)

and 25 min after nasal drops (T3)

as well as the sedation emotion score at mother-infant separation (T4)

Epworth Sleepiness Scale (ESS) at vein opening (T5)

and changes in pulse oxygen saturation (SpO2 ) and heart rate (HR) at various time points. Furthermore

the mask acceptance score during general anesthesia induction

agitation scores during recovery

and postoperative adverse drug reactions were compared. Results: The RASS scores at T1 to T3

ESS at T5 and agitation score during recovery in the observation group were significantly lower than those in the control group (P<0. 05). The sedation emotion score at T4 and the mask acceptance score during general anesthesia induction in the observation group were significantly higher than those in the control group (P<0. 05). The number of children who woke up and cried

the number of children who needed assisted anesthesia in the observation group were significantly less than those in the control group (P<0. 05). There was no significant difference in the changes of HR and SpO2 at T0 to T5 between two groups (P>0. 05). The incidence of adverse drug reactions between two groups was not statistically significant (P> 0. 05). Conclusion: Dexmedetomidine combined with hydromorphone preoperative nasal drops is safe and effective

facilitates quiet separation of children undergoing adenoidectomy from their parents

and has few adverse drug reactions

and deserves further application.

关键词

右美托咪定氢吗啡酮儿童术前滴鼻镇静母婴分离

Keywords

dexmetomidinehydromorphonechildrenpreoperative nasal sedationmother-infant separation

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