Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children

Pu Jie; Wu Wei; Li Zhijie; Ding Lan; Yang Ting

doi:10.13407/j.cnki.jpp.1672-108X.2023.11.014

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Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children

更新时间：2023-11-08

- Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children
- Vol. 29, Issue 11, Pages: 49-52(2023)
- 作者机构：
  
  无锡市儿童医院,江苏,无锡,214023
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.11.014
  CLC：
- Published：2023，
  
  Published Online：10 November 2023，
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Pu Jie, Wu Wei, Li Zhijie, et al. Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children. [J]. 29(11):49-52(2023)
DOI：

Pu Jie, Wu Wei, Li Zhijie, et al. Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children. [J]. 29(11):49-52(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.11.014.

摘要

目的:评估 2%克立硼罗软膏治疗儿童轻中度特应性皮炎的疗效和安全性。方法:84 例轻中度儿童特应性皮炎随机分为治疗组 47 例和对照组 37 例

分别接受 2%克立硼罗软膏+润肤剂和单用润肤剂治疗

疗程为 4 周

比较两组患儿有效率和瘙痒改善程度。结果:治疗组和对照组的有效率分别为 72. 34%和 27. 03%

差异有统计学意义(P<0. 01)。治疗组瘙痒评分较对照组改善明显

尤以夜间瘙痒和动态瘙痒评分改善为主。治疗组瘙痒改善率 63. 83%

明显高于对照组的 13. 51%。药物不良反应少见

仅为一过性局部刺激。结论:2%克立硼罗软膏治疗儿童轻中度特应性皮炎安全有效。

Abstract

Objective: To evaluate the efficacy and safety of 2% crisaborole ointment in the treatment of mild to moderate atopic dermatitis in children. Methods: A total of 84 children with mild to moderate atopic dermatitis were randomly divided into 47 cases in the treatment group and 37 cases in the control group

respectively treated with 2% crisaborole ointment+emollients and emollients alone for 4 weeks. The effective rate and degree of pruritus improvement in two groups were compared. Results: The effective rate of treatment group and control group were respectively 72. 34% and 27. 03%

with statistically significant difference (P<0. 01). The score of pruritus in the treatment group was significantly improved compared with the control group

with a particular predominance of improvement in nocturnal pruritus and dynamic pruritus score. The improvement rate of pruritus in the treatment group was 63. 83%

significantly higher than 13. 51% in the control group. Adverse drug reactions were rare

only transient local stimulation. Conclusion: 2% crisaborole ointment is safe and effective in the treatment of mild to moderate atopic dermatitis in children.

关键词

特应性皮炎儿童克立硼罗疗效评价安全性

Keywords

atopic dermatitischildrencrisaboroleefficacy evaluationsafety

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