To explore safe and effective management in drug expiry dates in emergency pharmacy. Methods: A total of 347 types of drugs with expiry dates from Jan. to Jun. 2021 were selected as the research subjects before implementation of Hazard Analysis and Critical Control Points (HACCP) management

and 353 types of drugs with expiry dates from Jul. to Dec. 2021 were extracted as the research subjects after implementation of HACCP management. Comparative analysis was performed to assess the circulation of near- expiry drugs in the emergency pharmacy before and after implementation of HACCP management. The specific steps included forming working group

establishing workflow diagram

analyzing hazards

assessing risks

identifying critical control points ( CCP)

setting critical limits ( CL)

developing and implementing HACCP regimen

and maintaining records. Results: After implementation of HACCP management

the proportion of near-expiry drugs in emergency pharmacy of the hospital decreased

from 3. 09% to 0. 84% ( P<0. 05). The drug wastage rate also decreased

from 0. 94‰ to 0. 19‰ (P<0. 05). Conclusion: The implementation of HACCP management in drug expiry dates in emergency pharmacy has yielded significant results and is worthy of wider promotion and application.