Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma

Li Yinfang; Kong Xia; Wu Hongmei

doi:10.13407/j.cnki.jpp.1672-108X.2023.10.013

您当前的位置：

首页 >

文章列表页 >

Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma

更新时间：2023-09-30

- Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma
- Vol. 29, Issue 10, Pages: 45-48(2023)
- 作者机构：
  
  南京医科大学附属南京医院,南京市第一医院,南京,210006
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.10.013
  CLC：
- Published：2023，
  
  Published Online：10 October 2023，
扫描看全文
Li Yinfang, Kong Xia, Wu Hongmei. Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma. [J]. 29(10):45-48(2023)
DOI：

Li Yinfang, Kong Xia, Wu Hongmei. Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma. [J]. 29(10):45-48(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.10.013.

摘要

目的:探讨益生菌对过敏性哮喘患儿体内炎症因子及氧化应激标志物水平的影响。方法:选取 2016 年 2 月至 2019 年 12 月南京市第一医院哮喘门诊确诊的 62 例过敏性哮喘患儿

随机分为对照组和观察组各 31 例。对照组仅予以常规抗哮喘治疗

观察组在对照组治疗基础上予以口服益生菌。采用儿童哮喘控制测试(C-ACT)量表比较两组患儿治疗前后哮喘控制效果

记录第1 秒用力呼气容积(FEV1)、FEV1 占肺活量(FVC)百分比(FEV1/ FVC)、呼气峰流速(PEF)

检测血清中白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)水平。结果:治疗前

两组患儿哮喘控制效果、FVC、FEV1、PEF

血清 IL-4、IFN-γ、MDA、SOD、GSH 水平比较差异均无统计学意义(P>0. 05)。治疗后

两组患儿哮喘控制效果、FVC、FEV1、PEF 均较治疗前显著改善

且观察组改善程度优于对照组(P 均<0. 05);两组患儿 IL-4、MDA 水平均较治疗前明显降低

且观察组较对照组降低更明显(P 均<0. 05)。两组患儿 IFN-γ、SOD、GSH 水平均较治疗前明显升高

且观察组较对照组升高更明显(P 均<0. 05)。结论:益生菌辅助治疗可改善过敏性哮喘患儿哮喘控制效果及肺功能

降低哮喘患儿体内促炎因子及氧化应激标志物水平

增加抗炎因子及抗氧化物表达水平。因此

益生菌可能通过抗炎及抗氧化作用机制干预哮喘

是潜在的辅助治疗哮喘的药物。

Abstract

Objective: To explore the effects of probiotics on levels of inflammatory factors and oxidative stress markers in children with allergic asthma. Methods: A total of 62 children diagnosed with allergic asthma at the asthma outpatient department of the First Hospital of Nanjing from Feb. 2016 to Dec. 2019 were randomly divided into the control group and observation group

with 31 cases in each group. The control group received routine anti-asthmatic treatment

while the observation group was given oral probiotics based on the control group. The children’s asthma control test (C-ACT) was used to compare the asthma control effects before and after treatment in both groups. The forced expiratory volume at one second ( FEV1)

FEV1 / forced vital capacity ( FVC)

and peak expiratory flow (PEF) were recorded. The levels of interleukin-4 ( IL-4)

interferon-γ ( IFN-γ)

malondialdehyde ( MDA)

superoxide dismutase ( SOD) and reduced glutathione (GSH) in the serum were measured. Results: Before treatment

there were no significant differences in asthma control effects

FVC

FEV1

PEF

IL-4

IFN-γ

MDA

SOD and GSH levels between two groups (P>0. 05). After treatment

both groups showed significant improvements in asthma control effects

FVC

FEV1 and PEF compared with those before treatment

and the observation group was better than the control group (P<0. 05). The IL-4 and MDA levels in both groups decreased significantly after treatment

with a more significant decrease in the observation group compared with the control group (P<0. 05). The levels of IFN-γ

SOD and GSH in both groups increased significantly after treatment

with a more significant increase in the observation group compared with the control group (P<0. 05). Conclusion: Probiotic supplementation can improve asthma control effects and pulmonary function in children with allergic asthma

reduce the levels of pro-inflammatory factors and oxidative stress markers

and increase the expression levels of anti-inflammatory factors and antioxidants. Therefore

probiotics may potentially serve as the adjunctive treatment for asthma by modulating anti-inflammatory and antioxidant mechanisms.

关键词

支气管哮喘白细胞介素-4γ-干扰素丙二醛超氧化物歧化酶

Keywords

bronchial asthmainterleukin-4interferon-γmalondialdehvdesuperoxidate dismatas

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy of Cetirizine Hydrochloride Drops Combined with Fluticasone Propionate Inhalation in theTreatment of Allergic Rhinitis Complicated with Bronchial Asthma in Children

Current Status and Clinical Evaluation of Asthma Medication in Children: Based on Survey Results of 46 Medical Institutions

Salbutamol and Ipratropium Bromide Combined with Magnesium Sulfate in the Treatment of Children with Acute Attack of Bronchial Asthma

Efficacy of Procaterol Combined with Montelukast in the Treatment of Bronchial Asthma in Children

Effects of Montelukast Combined with Vitamin D Preparations on Pulmonary Function, Oxidation-antioxidant Imbalance and Quality of Life in Children with Bronchial Asthma

Related Author

Wang Hongmei

Dong Liangliang

Huang Mengmeng

Wang Xiaoling

Xiang Li

Cao Wang

Jia Lulu

Huang Huijie

Related Institution

Liaocheng Second People’s Hospital, Shandong Liaocheng

National Children’s Medical Center, Beijing Children’s Hospital, Capital Medical University

The Second People’s Hospital of Hefei

Xiangyang No. 1 Prople’s Hospital, Affiliated Hospital of Hubei University of Medicine, Hubei Xiangyang

Maternal and Child Health Care Hospital of Lishui

⁰