Objective: To formulate and implement the intervention regimen for the key monitoring of creatine phosphate sodium in pediatrics

so as to promote the rational use in clinic. Methods: Medical orders of pediatric patients received creatine phosphate sodium in our hospital from Nov. 2020 to Apr. 2021 were collected

and 300 medical orders were selected for special review. In view of theproblems found in the review

intervention was carried out through training and education

strengthening the review of medical orders and medication monitoring

and establishing the approval process for drug use. And 300 medical orders from May to Oct. 2021 were selected by the same method. The use of creatine phosphate sodium before and after intervention was compared and analyzed. Results: After pharmacists’ intervention

the utilization rate of creatine phosphate sodium decreased from 15. 96% to 4. 84%

and the consumption sum decreased from 3. 516

5 million yuan to 1. 344

4 million yuan. Of the 35 inpatient departments

33 departments showed a decrease in the consumption sum

of which 16 departments did not use the drug anymore. The rational utilization rate of creatine phosphate sodium increased from 62. 33% to 93. 67%

the difference was statistically significant (P< 0. 05). Conclusion: The rational use of creatine phosphate sodium can be promoted through training and education

strengthening the review of medical orders and medication monitoring

and establishing the approval process for drug use.