Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021

Zhao Hua; Gong Zhanchao; Du Xiaoqun; Guo Shenglan; Lin Chuanzhong; Luo Chongbin

doi:10.13407/j.cnki.jpp.1672-108X.2023.05.013

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Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021

更新时间：2023-05-19

- Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021
- Vol. 29, Issue 5, Pages: 46-49(2023)
- 作者机构：
  
  广州市花都区人民医院,广州,510800
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.013
  CLC：
- Published：2023，
  
  Published Online：10 May 2023，
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Zhao Hua, Gong Zhanchao, Du Xiaoqun, et al. Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021. [J]. 29(5):46-49(2023)
DOI：

Zhao Hua, Gong Zhanchao, Du Xiaoqun, et al. Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021. [J]. 29(5):46-49(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.05.013.

摘要

目的:了解某院新生儿科2019-2021 年多重耐药菌构成及耐药情况

为临床合理使用抗菌药物提供参考。方法:收集某院2019-2021 年新生儿科154 例新生儿发生多重耐药感染的细菌监测数据

分别从多重耐药检出率、一般情况、标本来源分布、多重耐药菌株构成等方面进行分析。结果:2019-2021 年154 例新生儿共检出多重耐药菌株166 株

痰液、血液、支气管分泌物占标本来源构成的前三位。以早产儿及低出生体质量儿发生多重耐药菌感染占比较大

检出的多重耐药菌以产超广谱β-内酰胺酶菌(ESBLs)的大肠埃希菌和肺炎克雷伯菌为主

检出率总体呈下降趋势。药敏试验结果显示大肠埃希菌、肺炎克雷菌对头孢呋辛、头孢曲松耐药率100%

对厄他培南、亚胺培南的敏感率100%。结论:某院新生儿科2019-2021 年多重耐药菌感染的病原菌以革兰阴性菌为主

且对大部分抗菌药物产生耐药。

Abstract

Objective: To understand the composition and use of multiple drug-resistant bacteria in neonatal department of a hospital

and to guide the rational use of antibiotics in clinic. Methods: The bacterial surveillance results of multiple drug resistance infection in 154 newborns in the department of neonatal department of a hospital from 2019 to 2021 were analyzed from the detection rate of multiple drug resistance

the general condition of newborns

the source distribution of samples

and the composition of multiple drug resistant strains. Results: A total of 166 strains of multiple drug-resistant bacteria were detected from the 154 neonates from 2019 to 2021

and the top 3 sources of samples were sputum

blood

and bronchial secretions. The incidence of multiple drug resistance infection was higher in premature and low birth weight infants

and the main multi-drug resistant bacteria detected were producing ESBLs Escherichia coli and Klebsiella pneumoniae. The detection rate showed downward trend in general. The drug sensitivity results showed that the resistance rate of Escherichia coli and Klebsiella pneumoniae to cefuroxime and ceftriaxone was 100%

and the sensitive rate to ertapenem and imipenem was 100%. Conclusion: The main pathogens infected by multiple drug-resistant bacteria in neonatal department of the hospital are Gram-negative bacteria and are resistant to most antibiotics.

关键词

新生儿多重耐药感染抗菌药物

Keywords

newbornmulti-drug resistancenfectionantibiotics

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