Objective: To analyze the effect of vitamin A combined with insulin detemir-insulin aspart on glycolipid metabolism and insulin resistance in children with diabetes

and provide basis for clinical application. Methods: A total of 114 children with type 1 diabetes admitted to our hospital from 2019 to 2021 were divided into observation group and control group in average. The control group was treated with insulin detemir + insulin aspartate

and the observation group was treated with insulin detemir + insulin aspartate combined with vitamin A. Both groups were treated for 12 weeks as the observation time point after treatment. The function of residual pancreatic β cells

glycolipid metabolism

oxidative stress level

blood glucose target time

total daily dosage of insulin

occurrence of hypoglycemia and occurrence of complications were compared between the two groups. Results: After treatment

HOMA-β

HDL-C

NO and SOD of observation group were significantly higher than those of control group

while HOMA-IR

TG

TC

LDL-C

FPG

MDA

8-OhdG and 8-iso-PGF2α of observation group were significantly lower than those of control group (P<0. 05). After treatment

the incidence of hypoglycemia in the observation group was lower than that in the control group

and the incidence of hypoglycemia in the patients with hypoglycemia was lower than that in the control group

while the level of hypoglycemia was higher (P <0. 05). After treatment

the blood glucose reaching time

the total daily dosage of insulin aspartate and insulin detemir in observation group were significantly lower than those in control group (P<0. 05). After treatment

the incidence of retinopathy

albuminuria and hepatitis in observation group was lower than that in control group

and there was statistical significance (P <0. 05). Conclusion: Vitamin A combined with insulin detemir-insulin aspart can significantly improve glycolipid metabolism and insulin resistance in children with diabetes after intervention

which has high application value.