Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data

Liu Ye; Bu Jun

doi:10.13407/j.cnki.jpp.1672-108X.2023.05.009

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Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data

更新时间：2023-05-19

- Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data
- Vol. 29, Issue 5, Pages: 30-34(2023)
- 作者机构：
  
  上海交通大学医学院附属上海儿童医学中心,上海,200135
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.009
  CLC：
- Published：2023，
  
  Published Online：10 May 2023，
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Liu Ye, Bu Jun. Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data. [J]. 29(5):30-34(2023)
DOI：

Liu Ye, Bu Jun. Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data. [J]. 29(5):30-34(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.05.009.

摘要

目的:系统评价输血与极低出生体质量新生儿发生坏死性小肠结肠炎( NEC) 的相关性。方法:计算机检索EMBase、 PubMed、the Cochrane Library 数据库等收集极低出生体质量新生儿输血相关性NEC 的病例研究及随机对照试验

检索时限从建库至2021 年12 月。由2 名评价者独立筛选文献、提取资料和评估方法学质量后

采用RevMan 5. 3 软件进行Meta 分析。结果: 本研究最终纳入17 篇文献

其中3 篇为队列研究

14 篇为病例对照研究。17 篇文献中

3 篇研究结果提示输血可增加极低出生体质量新生儿发生NEC 的风险

14 篇提示输血并未显著增加极低体质量新生儿发生NEC 的风险。在合并纳入17 篇文献研究结果后

发现输血并未显著增加极低出生体质量新生儿发生NEC 的风险(OR= 1. 44

95%CI 0. 87~2. 37

P>0. 05)。结论:输血并未显著增加极低出生体质量新生儿发生NEC 的风险。

Abstract

Objective: To evaluate the relationship between blood transfusion and the incidence of necrotizing enterocolitis (NEC) in very low birth weight infants. Methods: Several databases

such as Embase

PubMed and the Cochrane Library

were retrieved to obtain relevant case studies and randomized controlled trials of transfusion-related NEC in very low birth weight infants

and other sources for case studies and randomized controlled trials related to blood transfusion-induced NEC in very low birth weight infants from the database establishment to December 2021. The relevant literature

data

and methodological quality were extracted and evaluated by two reviewers independently. Meta-analysis was conducted using RevMan 5. 3 software. Results: In total

17 articles were included in this study

3 of which were cohort studies

and 14 of them were case control studies. Among the 17 studies

three suggested that blood transfusion could significantly increase the risk of NEC in very low birth weight infants

while 14 suggested that blood transfusion did not significantly increase the risk of NEC in very low birth weight infants. After combining the results of 17 literatures

it was found that blood transfusion did not significantly increase the risk of NEC in very low birth weight newborns (OR=1. 44

95%CI 0. 87-2. 37

P> 0. 05. Conclusion: Blood transfusion cannot significantly alter the risk of NEC in very low birth weight neonates.

关键词

极低出生体质量新生儿坏死性小肠结肠炎Meta 分析输血

Keywords

ery low birth weight infantnecrotizing enterocolitisMeta-analysisblood transfusion

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