Analysis of Digoxin Application and Therapeutic Drug Monitoring in 104 Newborns

Liu Manman; Zhang Shunguo

doi:10.13407/j.cnki.jpp.1672-108X.2023.05.006

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Analysis of Digoxin Application and Therapeutic Drug Monitoring in 104 Newborns

更新时间：2023-05-19

- Analysis of Digoxin Application and Therapeutic Drug Monitoring in 104 Newborns
- Vol. 29, Issue 5, Pages: 21-24(2023)
- 作者机构：
  
  上海交通大学医学院附属上海儿童医学中心,上海,200127
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.006
  CLC：
- Published：2023，
  
  Published Online：10 May 2023，
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Liu Manman, Zhang Shunguo. Analysis of Digoxin Application and Therapeutic Drug Monitoring in 104 Newborns. [J]. 29(5):21-24(2023)
DOI：

Liu Manman, Zhang Shunguo. Analysis of Digoxin Application and Therapeutic Drug Monitoring in 104 Newborns. [J]. 29(5):21-24(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.05.006.

摘要

目的:分析我院新生儿地高辛的使用与治疗药物监测( TDM) 情况

为临床合理用药提供参考。方法:收集我院2016- 2020 年应用地高辛的新生儿病例

对患儿一般资料、地高辛用药剂量、给药频率、给药途经、治疗药物监测情况及临床结局进行回顾性分析。结果:共纳入104 例应用地高辛的住院新生儿

其中早产儿43 例

足月儿61 例

维持剂量分别为(7. 0±2. 4)、(8. 2± 1. 5)μg/ (kg·d)。约96. 2%的患儿采用q12h 给药

93. 3%患儿口服给药。78 例(75. 0%)患儿开展了TDM

以0. 5~2. 0 ng/ mL 为谷浓度参考范围

有25 例(24. 0%)患儿血浆药物浓度超出参考范围上限

无低于参考范围下限的病例。早产儿与足月儿按推荐剂量给药时血药浓度均为(1. 7±0. 7)ng/ mL

临床治愈率分别为50. 0%和61. 8%。结论:新生儿尤其早产儿对地高辛较为敏感

建议密切监测药物浓度与不良反应

临床药师可提供新生儿地高辛个体化药学服务

促进临床合理用药。

Abstract

Objective: To analyze the therapeutic drug monitoring and treatment situation of digoxin in neonates and provide references for clinical rational use of digoxin. Methods: The neonatal cases using digoxin in our hospital from 2016 to 2020 were collected

and the patient data

digoxin dosage

administration frequency

routes

therapeutic drug monitoring and clinical outcomes were retrospectively analyzed. Results: A total of 104 hospitalized neonates treated with digoxin were enrolled

including 43 preterm infants and 61 term infants and the average maintenance dose of digoxin was (7. 0±2. 4) and (8. 2±1. 5) μg/ (kg·d)

respectively. About 96. 2% of the children were administered with q12h frequency

and 93. 3% were administered orally. And 78 children underwent therapeutic drug monitoring

with 0. 5 to 2. 0 ng/ mL as the reference range of trough concentration

among which

the drug concentrations of 25(24. 0%) children exceeded the upper limit of the reference value

and no case was lower than the lower limit of the reference value. The average drug concentration of preterm infants and full-term infants at the recommended doses were both (1. 7±0. 7) ng/ mL

respectively

and the clinical cure rates were 50. 0% and 61. 8%

respectively. Conclusion: Neonates

especially premature infants

are sensitive to digoxin. It is recommended to closely monitor the drug concentration and adverse reactions. Clinical pharmacists can provide individualized pharmaceutical services for neonates to promote clinical rational drug use.

关键词

地高辛新生儿治疗药物监测回顾性研究

Keywords

goxinneonatetherapeutic drug monitoringretrospective study

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