Effect and Intervention of Rifampicin Combined with Cyclosporine A on Nephrotic Syndrome Complicated with Tuberculosis Infection in Children

Li Shu; Zhang Aiguo; Zhao Yiming; Wang Xiaoling

doi:10.13407/j.cnki.jpp.1672-108X.2023.05.005

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Effect and Intervention of Rifampicin Combined with Cyclosporine A on Nephrotic Syndrome Complicated with Tuberculosis Infection in Children

更新时间：2023-05-19

- Effect and Intervention of Rifampicin Combined with Cyclosporine A on Nephrotic Syndrome Complicated with Tuberculosis Infection in Children
- Vol. 29, Issue 5, Pages: 17-21(2023)
- 作者机构：
  
  1. 华北理工大学附属医院,河北,唐山,063000
  2. 首都医科大学附属北京儿童医院,北京,100045
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.005
  CLC：
- Published：2023，
  
  Published Online：10 May 2023，
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Li Shu, Zhang Aiguo, Zhao Yiming, et al. Effect and Intervention of Rifampicin Combined with Cyclosporine A on Nephrotic Syndrome Complicated with Tuberculosis Infection in Children. [J]. 29(5):17-21(2023)
DOI：

Li Shu, Zhang Aiguo, Zhao Yiming, et al. Effect and Intervention of Rifampicin Combined with Cyclosporine A on Nephrotic Syndrome Complicated with Tuberculosis Infection in Children. [J]. 29(5):17-21(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.05.005.

摘要

目的:通过对3 例肾病综合征(NS)合并结核感染患者联合应用环孢素(CsA) 与利福平(RFP) 的监护与干预

探讨临床药师基于血药浓度监测在药学监护和识别药物相互作用中发挥的作用。方法:临床药师通过血药浓度监测分析与RFP 联用及停药后的CsA 血药浓度变化情况

揭示RFP 与CsA 的相互作用及持续时间

寻找有效治疗方案。结果:CsA 与RFP 联用后

采取多种措施

均未上升到有效血药浓度。停用RFP 1 周CsA 血药浓度可上升至有效血药浓度

且RFP 的诱导作用仍然存在。 RFP 可显著降低CsA 的血药浓度

且作用时间持久

应避免二者联用。结论:临床药师通过血药浓度监测

参与优化药物治疗

成功干预了药物相互作用

保障了患者的用药安全

促进临床合理用药。

Abstract

Objective: To explore the role of blood concentration monitoring by clinical pharmacists in pharmaceutical care and identification of drug interactions through monitoring and intervening cyclosporine A (CsA) and rifampicin (RFP) in 3 patients with nephrotic syndrome (NS) complicated with tuberculosis infection. Methods: Blood concentration monitoring was used as a technical support to analyze the changes of CsA plasma concentration after combination with RFP and withdrawal of RFP

revealing the severity and duration of their interactions. Based on this

the pharmacists sought an effective treatment. Results: The plasma concentration of CsA didn’t rise to the effective concentration by taking multiple measures in combination with RFP. However

it rose to be effective after 7 days’ withdrawal of RFP

and the RFP induction still existed. These results indicated that RFP can significantly and persistently reduce the blood concentration of CsA

and the combined therapy should be avoided. Conclusion: Through blood drug concentration monitoring

pharmacists have participated in the optimization of drug treatment

successfully intervened the drug interaction

ensured the safety of patients

and promoted the rational drug use in clinic.

关键词

利福平环孢素血药浓度监测药物相互作用

Keywords

rifampicincyclosporine Ablood concentration monitoringrug interaction

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