Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia inChildren

Que Jun; Huang Bin; Zheng Jianbin; Chen Hengdao; Xiao Jinrong; Zhan Meixiang

doi:10.13407/j.cnki.jpp.1672-108X.2023.04.013

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Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia inChildren

更新时间：2023-04-28

- Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia inChildren
- Vol. 29, Issue 4, Pages: 47-50(2023)
- 作者机构：
  
  1. 联勤保障部队第九〇〇医院,福州,350001
  2. 宁德师范学院附属宁德市医院,福建,宁德,352100
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.04.013
  CLC：
- Published：2023，
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Que Jun, Huang Bin, Zheng Jianbin, et al. Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia inChildren. [J]. 29(4):47-50(2023)
DOI：

Que Jun, Huang Bin, Zheng Jianbin, et al. Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia inChildren. [J]. 29(4):47-50(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.04.013.

摘要

目的:探讨瑞马唑仑降低小儿七氟烷麻醉后躁动发生率的效果及安全性

为提高儿科麻醉质量提供参考。方法:选取 2020 年3 月至2021 年3 月联勤保障部队第九〇〇医院收治的需行腹腔镜疝囊高位结扎手术患儿90 例

按随机数表法分为 A 组与B 组各45 例

A 组患儿给予七氟烷麻醉

B 组给予瑞马唑仑联合七氟烷麻醉

比较两组患儿麻醉效果(麻醉诱导时间、呼吸恢复时间、苏醒时间、拔管时间)、生命体征变化情况( 平均动脉压、心率)、苏醒期躁动情况[ 苏醒期躁动( PAED) 评分、激动 (Watcha)评分、躁动发生率] 及不良反应发生情况。结果:B 组患儿麻醉诱导时间、呼吸恢复时间、苏醒时间均短于A 组 (P<0. 05)。B 组麻醉诱导时、术毕时、清醒时平均动脉压与心率均高于A 组(P<0. 05)。B 组PAED 评分、Watcha 评分及躁动发生率低于A 组(P<0. 05)。两组不良反应发生率比较差异无统计学意义(P>0. 05)。结论:瑞马唑仑在小儿七氟烷麻醉中的应用效果显著

可提高麻醉效果

稳定患儿生命体征

降低小儿七氟烷麻醉后躁动发生率

且不增加不良反应

有效性与安全性均较高。

Abstract

Objective: To observe the effect and safety of remazolam in reducing the incidence of agitation after sevoflurane anesthesia in children

and to provide theoretical support for improving the quality of anesthesia in children. Methods: A total of 90 children who needed laparoscopic high ligation of hernia sac in the Department of Anesthesia and Perioperative Medicine of The 900th Hospital of Joint Logistics Support Force

PLA from March 2020 to March 2021 were randomly divided into group A and group B

with 45 cases in each group. Group A was given sevoflurane anesthesia

and group B was given combined anesthesia of remazolam and sevoflurane. The anesthetic effect (anesthesia induction time

respiratory recovery time

awakening time

extubation time)

changes of vital signs (mean arterial pressure

heart rate)

agitation during recovery such as pediatric anesthesia emergence delirium (PAED) score

Watcha score

incidence of agitation and adverse reactions were compared between the two groups. Results: The anesthesia induction time

respiratory recovery time and awakening time in group B were shorter than those in group A (P<0. 05). The mean arterial pressure and heart rate in group B were higher than those in group A (P<0. 05). The PAED score and Watcha score of group B were higher than those of group A

and the incidence of agitation was lower in group B than in group A (P<0. 05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P >0. 05). Conclusion: The application effect of remazolam in sevoflurane anesthesia in children is significant

which can improve the anesthetic effect

stabilize the vital signs of children

reduce the incidence of agitation after sevoflurane anesthesia in children

and does not increase adverse reactions. It has high effectiveness and safety

and is worthy of application.

关键词

瑞马唑仑儿童腹腔镜疝囊高位结扎手术七氟烷麻醉躁动安全性

Keywords

remazolamchildrenlaparoscopic high ligation of hernia sacsevofluraneanesthesiaagitationsafety

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