Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range

Yu Jing; He Lei; Palati·Reheman; Feng Jirong; Sun Yan

doi:10.13407/j.cnki.jpp.1672-108X.2023.04.002

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Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range

更新时间：2023-04-28

- Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range
- Vol. 29, Issue 4, Pages: 7-10(2023)
- 作者机构：
  
  新疆维吾尔自治区儿童医院,北京儿童医院新疆医院,乌鲁木齐,830000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.04.002
  CLC：
- Published：2023，
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Yu Jing, He Lei, Palati·Reheman, et al. Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range. [J]. 29(4):7-10(2023)
DOI：

Yu Jing, He Lei, Palati·Reheman, et al. Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range. [J]. 29(4):7-10(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.04.002.

摘要

目的:探讨新疆地区癫痫患儿拉考沙胺(LCM)稳态血药浓度的影响因素

初步建立LCM 稳态血药浓度的参考范围

为临床个体化用药提供参考。方法:收集新疆地区规律服用LCM 并达到稳态血药浓度的4~14 岁癫痫患儿313 例

测定血药浓度

分析年龄、性别、民族、剂量、合并用药等因素对血药浓度的影响

并初步建立稳态血药浓度的参考范围。结果:新疆地区癫痫患儿的LCM 浓度剂量比(CDR)无性别和民族差异(P>0. 05);4~6 岁组给药剂量高于7~14 岁组

而CDR 低于7~14 岁组 (P 均<0. 01);LCM 单药组给药剂量和血药浓度低于LCM+其他抗癫痫药物组(P 均<0. 05)。总体LCM 稳态血药浓度参考范围为2. 02~14. 47 μg/ mL。结论:临床使用LCM 控制和治疗儿童癫痫的过程中

有必要进行治疗药物监测

以便及时调整剂量

更好地控制癫痫发作。

Abstract

Objective: To explore the factors affecting the steady-state plasma concentration of lacosamide (LCM) in children with epilepsy in Xinjiang

and to establish the reference range of steady-state plasma concentration of LCM

so as to provide theoretical basis for clinical individualized drug use. Methods: The serum drug concentration was collected and measured in 313 children with epilepsy in Xinjiang who regularly took LCM and reached steady-state blood concentration

and the effects of age

gender

ethnicity

dosage and combined use on the serum concentration of LCM were analyzed

and the reference range of steady-state serum concentration of LCM was preliminarily established. Results: There was no significant difference in LCM concentration-dose ratio (CDR) values among children with epilepsy of different genders and ethnic groups (P>0. 05). The dosage of the 4 to 6 age group was significantly higher than that of the 7 to 14 age group

and the CDR results of the 7 to 14 age group were significantly higher than that of the 4 to 6 age group (all P< 0. 01). The concentration results of the children in the LCM single drug group were significantly lower than those of the LCM combined with other antiepileptic drugs groups (all P<0. 05). The reference range of steady-state blood concentration of LCM in this study was 2. 02-14. 47 μg/ mL. Conclusion: During the clinical use of LCM to control and treat epilepsy in children

it is necessary to monitor the therapeutic drug of LCM in order to adjust its dosage in time and better control epileptic seizures.

关键词

癫痫儿童拉考沙胺血药浓度参考范围

Keywords

epilepsychildrenlacosamideplasma concentrationreference range

references

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