The Safety of Esketamine Combined with Dexmedetomidine for Pediatric Painless Fiberoptic Bronchoscopy

Ji Yingying; Jiang Jing; Hou Huiyan; Dan Yingzhi

doi:10.13407/j.cnki.jpp.1672-108X.2023.03.009

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The Safety of Esketamine Combined with Dexmedetomidine for Pediatric Painless Fiberoptic Bronchoscopy

更新时间：2023-04-14

- The Safety of Esketamine Combined with Dexmedetomidine for Pediatric Painless Fiberoptic Bronchoscopy
- Vol. 29, Issue 3, Pages: 32-35(2023)
- 作者机构：
  
  上海交通大学附属上海儿童医学中心,上海,200127
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.03.009
  CLC：
- Published：2023，
  
  Published Online：10 March 2023，
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Ji Yingying, Jiang Jing, Hou Huiyan, et al. The Safety of Esketamine Combined with Dexmedetomidine for Pediatric Painless Fiberoptic Bronchoscopy. [J]. 29(3):32-35(2023)
DOI：

Ji Yingying, Jiang Jing, Hou Huiyan, et al. The Safety of Esketamine Combined with Dexmedetomidine for Pediatric Painless Fiberoptic Bronchoscopy. [J]. 29(3):32-35(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.03.009.

摘要

目的:探讨右美托咪定联合艾司氯胺酮是否能够安全用于儿童纤维支气管镜(纤支镜)的检查;如果加用舒芬太尼

是否能够减少艾司氯胺酮的用量

降低不良反应发生率。方法:选取我院拟择期行纤支镜检查的患儿40 例

按随机数表法分为E 组和S 组各20 例。E 组采用“右美托咪定1 μg/ kg+艾司氯胺酮1 mg/ kg”麻醉方案

S 组采用“右美托咪定1 μg/ kg+艾司氯胺酮 1 mg/ kg+舒芬太尼0. 1 μg/ kg”麻醉方案。比较两组患儿基础(T0 )、诱导后(T1 )、纤支镜通过声门(T2 )、纤支镜通过隆突(T3 )、检查完成10 min(T4 )5 个时间点的心率(HR)、平均动脉压( MAP)、血氧饱和度( SpO2 ) 水平和不良反应。结果:E 组T2 、T3 的 HR 水平高于T1(P 均<0. 05)

T0 ~T4 的MAP、SpO2 水平变化差异均无统计学意义(P 均>0. 05)。S 组T0 ~T4 的HR、MAP、SpO2 水平变化差异均无统计学意义(P 均>0. 05)。两组患儿T0 ~T4 的MAP、SpO2 水平变化差异均无统计学意义(P 均>0. 05)。两组低氧血症发生率、艾司氯胺酮等药物用量比较差异均无统计学意义(P 均>0. 05)。结论:右美托咪定联合艾司氯胺酮能够安全用于儿童纤支镜的检查

加用舒芬太尼既不能减少艾司氯胺酮等药物的用量

也不能降低低氧血症等不良反应的发生率

所以没有必要。

Abstract

Objective: To explore the safety of painless anesthesia of dexmedetomidine combined with esketamine during fiberoptic bronchoscopy in children. If sufentanil is added

whether it can reduce the dosage of esketamine and reduce the incidence of adverse reactions. Methods: A total of 40 children who were scheduled to undergo fiberoptic bronchoscopy in our hospital were randomized into 2 groups in average

dexmedetomidine 1 μg/ kg + esketamine 1 mg/ kg (group E) and dexmedetomidine 1 μg/ kg + esketamine 1 mg/ kg + sufentanil 0. 1 μg/ kg (group S). The vital signs including heart rate (HR)

mean arterial pressure (MAP)

pulse oxyhemoglobin saturation (SpO2 ) and adverse reactions at basic (T0 )

after induction (T1 )

the fiberoptic bronchoscopy passing through the glottis (T2 )

the scope passing through the carina (T3 )

and 10 min after completion (T4 ) were observed and compared between the two groups. Results: The HR of T2 and T3 in the group E was significantly faster than that of T1 (all P<0. 05)

and there was no significant difference in MAP and SpO2 at T0 to T4 (all P>0. 05). There was no significant difference in HR

MAP and SpO2 at T0 to T4 between the two groups (all P>0. 05). There was no significant difference in the incidence of hyoxemia and drug dosage of esketamine between the two groups (all P>0. 05). Conclusion: Dexmedetomidine combined with esketamine can be used for pediatric fiberoptic bronchoscopy

but the additional use of sufentanil can not reduce the dosage of esketamine

nor the incidence of adverse reactions like hyoxemia. Thus

it’s no need of adding sufentanil.

关键词

右美托咪定艾司氯胺酮小儿纤维支气管镜

Keywords

exmedetomidineesketaminepediatricfiberoptic bronchoscopy

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