Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System

Nong Li; Mo Kai; Liang Ying; Qin Yan; Lan Xiaobu

doi:10.13407/j.cnki.jpp.1672-108X.2023.03.003

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Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System

更新时间：2023-04-14

- Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System
- Vol. 29, Issue 3, Pages: 10-13(2023)
- 作者机构：
  
  南宁市第一人民医院,南宁,530022
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.03.003
  CLC：
- Published：2023，
  
  Published Online：10 March 2023，
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Nong Li, Mo Kai, Liang Ying, et al. Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System. [J]. 29(3):10-13(2023)
DOI：

Nong Li, Mo Kai, Liang Ying, et al. Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System. [J]. 29(3):10-13(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.03.003.

摘要

目的:借助中国医院药物警戒系统(CHPS)的真实世界数据

评价某院儿童使用头孢唑肟的安全性

并分析头孢唑肟相关药物不良反应(ADR)发生情况及影响因素。方法:基于CHPS 平台

对我院2018 年2 月至2020 年4 月使用头孢唑肟的住院患儿进行单中心回顾性主动监测

药师对系统监测病例进行评定

获得头孢唑肟 ADR 发生率

并对ADR 影响因素进行分析。结果:系统共回顾性监测了2 948 例使用头孢唑肟的患儿

31 例出现ADR

ADR 发生率为1. 09%。多因素logistic 回归分析显示

头孢唑肟联合氟氯西林、单次用药剂量是儿童使用头孢唑肟发生ADR 的独立影响因素。结论:头孢唑肟在儿童用药中发生 ADR 并不少见。减少与氟氯西林联合用药、根据说明书推荐剂量用药有助于降低临床用药风险

CHPS 系统的应用对今后进行大样本量真实世界用药评价具有重要意义。

Abstract

Objective: Drawing on the real-world data from the China Hospital Pharmacovigilance System (CHPS)

to evaluate the safety of ceftizoxime used in children of a hospital

and analyze the occurrence of ceftizoxime-related adverse drug reaction (ADR) and its influencing factors. Methods: Based on the CHPS platform

single-center retrospective active monitoring was carried out on the hospitalized children who had ceftizoxime for injection from February 2018 to April 2020. The system monitoring cases were evaluated by double pharmacists

the incidence of ceftizoxime ADR was obtained

and its influencing factors were analyzed. Results: Totally 2

948 children who used ceftizoxime were monitored retrospectively

and 31 cases of ADR occurred

with an incidence of 1. 09%. Multivariate logistic regression analysis showed that the combination of ceftizoxime and flucloxacillin and a single dose were independent influencing factors of ADR in children using ceftizoxime. Conclusion: The incidence of ADR in children with ceftizoxime is not a rare range. Reducing the combined use of flucloxacillin and adjusting the single dose according to the weight of the child will help reduce the clinical risk of medication. The application of the CHPS platform is of great significance for future large-sample real-world medication evaluation.

关键词

中国医院药物警戒系统药物不良反应头孢唑肟儿童

Keywords

China Hospital Pharmacovigilance Systemadverse drug reactionceftizoximechildren

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