Clinical Analysis of 25 Cases of Neonatal Influenza A

Zhan Min; Wu Yunqin; Liang Minghui

doi:10.13407/j.cnki.jpp.1672-108X.2023.02.012

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Clinical Analysis of 25 Cases of Neonatal Influenza A

更新时间：2023-04-14

- Clinical Analysis of 25 Cases of Neonatal Influenza A
- Vol. 28, Issue 2, Pages: 46-50(2023)
- 作者机构：
  
  1. 湖南省儿童医院,长沙,410000
  2. 湖南省职业病防治院,长沙,410000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.02.012
  CLC：
- Published：2023，
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Zhan Min, Wu Yunqin, Liang Minghui. Clinical Analysis of 25 Cases of Neonatal Influenza A. [J]. 28(2):46-50(2023)
DOI：

Zhan Min, Wu Yunqin, Liang Minghui. Clinical Analysis of 25 Cases of Neonatal Influenza A. [J]. 28(2):46-50(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.02.012.

摘要

目的:探讨新生儿甲型流行性感冒的临床特点、治疗及预后。方法:回顾分析2018 年1 月至2020 年1 月湖南省儿童医院新生儿科收治的诊断为甲型流行性感冒的25 例住院新生儿临床资料

对患儿的临床特点、辅助检查、治疗过程及疾病转归进行分析。结果:25 例患儿中

男17 例

女8 例。16 例足月儿

9 例早产儿

其中7 例为晚期早产儿。18 例冬春季发病

7 例夏季发病。12 例发病前有“感冒”症状家人密切接触史。临床表现咳嗽17 例

发热17 例

呼吸困难10 例

鼻塞12 例

流涕3 例

呼吸暂停1 例。25 例患儿甲型流感病毒抗原检测均为阳性

6 例患儿同时呼吸道合胞病毒检测阳性

17 例痰细菌培养阳性。 16 例使用奥司他韦治疗

2 例使用帕拉米韦治疗。24 例治愈出院

1 例死亡

死亡患儿为早产儿。结论:新生儿甲型流感症状多不典型

冬季和夏季发病多见

预后大多较好

但早产儿需警惕严重并发症及不良预后。

Abstract

Objective: To explore the clinical characteristics

treatment and prognosis of neonatal influenza A. Methods: Clinical data of 25 hospitalized neonates diagnosed with influenza A in Neonatology Department of Hunan Children’s Hospital from January 2018 to January 2020 were analyzed retrospectively. The clinical characteristics

auxiliary examinations

treatment process and outcomes of the neonates were analyzed. Results: Among the 25 cases

17 were male and 8 were female. There were 16 full-term infants and 9 premature infants

among which 7 were late premature infants. Eighteen cases occurred in winter and spring

and 7 cases occurred in summer. Twelve cases had close contact with family members with symptoms of “cold” before ill. Clinical manifestations included cough in 17 cases

fever in 17 cases

dyspnea in 10 cases

nasal congestion in 12 cases

runny nose in 3 cases

and apnea in 1 case. All the 25 cases tested positive for influenza A virus antigen

6 cases tested positive for respiratory syncytial virus at the same time

and sputum bacteria culture was positive in 17 cases. Sixteen cases were treated with oseltamivir and 2 cases with peramivir. Twenty-four cases were cured and discharged

and 1 case died (a premature infant). Conclusion: The symptoms of influenza A infection in neonates are not typical

the incidence is usually high in winter and summer

and the prognosis is generally good

but the premature infants should be alert to serious complications and poor prognosis.

关键词

新生儿甲型流行性感冒

Keywords

neonatenfluenza A

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