Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis

Yang Meng; Yang Shujie; Gan Bin; Yi Haiying; Zhang Ping; Li Lei

doi:10.13407/j.cnki.jpp.1672-108X.2023.02.009

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Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis

更新时间：2023-04-14

- Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis
- Vol. 28, Issue 2, Pages: 35-38(2023)
- 作者机构：
  
  1. 武汉科技大学附属孝感医院,湖北,孝感,432000
  2. 武汉科技大学医学院,武汉,430065
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.02.009
  CLC：
- Published：2023，
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Yang Meng, Yang Shujie, Gan Bin, et al. Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis. [J]. 28(2):35-38(2023)
DOI：

Yang Meng, Yang Shujie, Gan Bin, et al. Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis. [J]. 28(2):35-38(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.02.009.

摘要

目的:探讨质量改进方案降低早产儿疑似早发败血症( EOS) 抗菌药物使用率的临床效果。方法:制订早产儿疑似EOS 抗菌药物使用临床质量改进方案

采用队列研究方法

选择2019 年10 月至2020 年12 月我院新生儿科收治的早产儿疑似EOS 患儿为观察组

收集2018 年6 月至2019 年6 月收治的早产儿疑似EOS 患儿为对照组。抗菌药物使用率、抗菌药物使用时间和感染反复情况为主要观察指标。结果:纳入研究的早产儿572 例

其中观察组242 例

对照组330 例

两组患儿一般资料比较差异均无统计学意义(P>0. 05)。观察组早产儿疑似EOS 抗菌药物使用率75. 98%

低于对照组的89. 69%;对照组每千住院日抗菌药物使用时间为329. 11 d

长于观察组的216. 05 d。两组均无死亡病例

住院期间停用抗菌药物后患儿感染相关的不良事件发生情况比较差异无统计学意义(P>0. 05)。结论:质量改进方案可减少早产儿疑似EOS 抗菌药物的使用率和使用时间。本研究可为早产儿抗菌药物的合理使用提供参考。

Abstract

Objective: To investigate the clinical effect of quality improvement on the utilization rate of antibacteria drug in premature infants suspected of early-onset sepsis (EOS). Methods: The clinical quality improvement program for the use of antibacteria drug in premature infants suspected of EOS was formulated

and cohort study was adopted. Children with suspected EOS in preterm infants admitted to the neonatal department of our hospital from October 2019 to December 2020 were selected as the observation group

and children with suspected EOS in preterm infants admitted from June 2018 to June 2019 were selected as the control group. The main outcome measures were antibacteria drug utilization rate

duration of antibacteria drug use

and recurrence of infection. Results:The study included 572 preterm infants

the observation group included 242 cases

and the control group included 330 cases. There was no significant difference in the clinical general data in the two groups (P>0. 05). The utilization rate of antibacteria drug in the observation group (75. 98%) was lower than that in the control group (89. 69%). The antibacteria drug use time of the control group (329. 11 days per 1

000 hospital days) was higher than that in the observation group (216. 05 days per 1

000 hospital days). There was no death in the two groups. There was either no significant difference in infection-related adverse events after antibacteria drug discontinuation during hospitalization (P>0. 05). Conclusion: Quality improvement can reduce the utilization rate and duration of suspected EOS antibacteria drug in preterm infants

providing theoretical basis for rational use of antibacteria drug in preterm infants.

关键词

败血症疑似抗菌药物质量改进早产儿

Keywords

sepsissuspecteantibacteria drugquality improvementpreterm infant

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