Efficacy and Safety of Infliximab in the Treatment of Intravenous Immunoglobulin Resistant Kawasaki Disease: A Systematic Review and Meta-Analysis

Wang Sibao; Pan Silin; Luo Gang; Ji Zhixian

doi:10.13407/j.cnki.jpp.1672-108X.2023.01.011

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Efficacy and Safety of Infliximab in the Treatment of Intravenous Immunoglobulin Resistant Kawasaki Disease: A Systematic Review and Meta-Analysis

更新时间：2023-04-14

- Efficacy and Safety of Infliximab in the Treatment of Intravenous Immunoglobulin Resistant Kawasaki Disease: A Systematic Review and Meta-Analysis
- Vol. 29, Issue 1, Pages: 34-38(2023)
- 作者机构：
  
  青岛大学附属妇女儿童医院,山东,青岛,266034
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.01.011
  CLC：
- Published：2023，
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Wang Sibao, Pan Silin, Luo Gang, et al. Efficacy and Safety of Infliximab in the Treatment of Intravenous Immunoglobulin Resistant Kawasaki Disease: A Systematic Review and Meta-Analysis. [J]. 29(1):34-38(2023)
DOI：

Wang Sibao, Pan Silin, Luo Gang, et al. Efficacy and Safety of Infliximab in the Treatment of Intravenous Immunoglobulin Resistant Kawasaki Disease: A Systematic Review and Meta-Analysis. [J]. 29(1):34-38(2023) DOI： 10.13407/j.cnki.jpp.1672-108X.2023.01.011.

摘要

目的:系统评价英夫利昔单抗(IFX)治疗静脉注射丙种球蛋白(IVIG) 无反应型川崎病(KD) 的有效性及安全性。方法: 计算机检索PubMed、the Cochrane Library、Medline、中国知网、万方数据库和中国生物医学文献数据库

收集各数据库从建库至 2020 年6 月有关IFX 治疗IVIG 无反应型KD 的文献

对符合纳入标准的文献应用RevMan 5. 3 进行Meta 分析。结果:共纳入 5 篇文献

包括IFX 治疗组(81 例)和再次IVIG 治疗对照组(211 例)。Meta 分析结果显示

IVIG 无反应型KD 患儿在首次IVIG 治疗无反应后

IFX 治疗组退热率明显高于再次IVIG 治疗对照组

差异有统计学意义(RR=1. 38

95%CI 1. 20~1. 59

P<0. 01)

但在冠状动脉损害(CALs)发生率及不良事件发生率方面两组患儿比较差异均无统计学意义(P>0. 05)。结论:目前证据表明

IVIG 无反应型KD 患儿在首次IVIG 治疗无反应后

应用IFX 治疗较再次应用IVIG 治疗能更有效地控制体温

但两者在CALs 发生率及不良事件发生率方面比较差异无统计学意义。

Abstract

Objective: To review the efficacy and safety of infliximab (IFX) in the treatment of intravenous immunoglobulin (IVIG) resistant Kawasaki disease ( KD). Methods: PubMed

the Cochrane Library

Medline

CNKI

Wanfang Database and Chinese Biological Medical Literature Databases were searched by computer

and the articles about IFX in the treatment of IVIG-resistant KD from the establishment of each database to June 2020 were collected. Meta-analysis was performed on the articles that met the inclusion criteria using Review Manager 5. 3. Results: A total of 5 articles were included

which was divided into IFX treatment group (81 cases) and re-IVIG treatment control group (211 cases). The results of Meta-analysis showed that the antipyretic rate in the IFX treatment group was significantly higher than that in the control group after the first IVIG treatment (RR=1. 38

95%CI 1. 20-1. 59

P<0. 01)

but there was no significant difference in the incidence of coronary artery lesions (CALs) and adverse events between the two groups (P>0. 05). Conclusion: At present

the evidence shows that after the first IVIG treatment

IFX treatment can control body temperature more effectively than IVIG treatment in children with IVIG resistant KD

but there is no significant difference in the incidence of CALs and adverse events between the two groups.

关键词

川崎病静脉注射丙种球蛋白英夫利昔单抗Meta 分析

Keywords

Kawasaki diseasentravenous immunoglobulinnfliximabMeta-analysis

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