Comparison of Anti-Allergic Drugs in National Essential Medicines List, World Health Organization Model List of Essential Medicines for Children and Other National Essential Medicines Lists

Ren Meijuan; Liu Lu; Gao Li; Yan Meixing

doi:10.13407/j.cnki.jpp.1672-108X.2022.11.003

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Comparison of Anti-Allergic Drugs in National Essential Medicines List, World Health Organization Model List of Essential Medicines for Children and Other National Essential Medicines Lists

更新时间：2023-04-14

- Comparison of Anti-Allergic Drugs in National Essential Medicines List, World Health Organization Model List of Essential Medicines for Children and Other National Essential Medicines Lists
- Vol. 28, Issue 11, Pages: 9-14(2022)
- 作者机构：
  
  1. 中国海洋大学,山东,青岛,266000
  2. 青岛市妇女儿童医院,山东,青岛,266000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.11.003
  CLC：
- Published：2022，
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Ren Meijuan, Liu Lu, Gao Li, et al. Comparison of Anti-Allergic Drugs in National Essential Medicines List, World Health Organization Model List of Essential Medicines for Children and Other National Essential Medicines Lists. [J]. 28(11):9-14(2022)
DOI：

Ren Meijuan, Liu Lu, Gao Li, et al. Comparison of Anti-Allergic Drugs in National Essential Medicines List, World Health Organization Model List of Essential Medicines for Children and Other National Essential Medicines Lists. [J]. 28(11):9-14(2022) DOI： 10.13407/j.cnki.jpp.1672-108X.2022.11.003.

摘要

目的：比较我国《国家基本药物目录》（NEML）、《世界卫生组织（WHO）儿童基本药物目录》（WHO-EMLc）和其他19个国家基本药物目录中抗变态反应药物的差异，为进一步完善我国基本药物目录提供参考。方法：检索WHO官网，收集各国基本药物目录。通过Excel分析工具，比较抗变态反应药物种类、数量、剂型、规格等的差异，探讨基本药物对儿童的适宜性，总结收录的抗变态反应药物在我国的上市情况。结果：NEML与WHO-EMLc中相同的抗变态反应药物为氯雷他定。与NEML比较，WHO-EMLc和其他19国目录中抗变态反应药物增加了适合儿童使用的口服溶液剂，且部分国家注明了氯苯那敏和西替利嗪药物的年龄限制。各目录中收录的抗变态反应药物在我国上市剂型主要为普通片剂，适合儿童使用的颗粒剂、糖浆剂等特殊剂型虽有上市，但生产厂家较少。结论：以NEML与WHO-EMLc为基础，借鉴瑞典、马来西亚、马尔代夫等国家的经验，建议适当增加适宜儿童使用的第二代抗组胺药物剂型和规格，保障儿童临床用药的安全有效，完善国家基本药物目录

Abstract

Objective: To compare the differences of anti-allergic drugs in National Essential Medicines List (NEML)

World Health Organization (WHO) Model List of Essential Medicines for Children (WHO-EMLc) and other 19 national essential medicines lists

so as to provide reference for further improving the essential medicines list of China. Methods: WHO official website was searched to collect essential medicines list in different countries. Through Excel analysis

differences in the types

quantities

dosage forms and specifications of anti-allergic drugs were compared

the suitability of essential medicines for children was discussed

and the listing of anti-allergic drugs in China was summarized. Results: Loratadine was the same anti-allergic drug in WHO-EMLc and NEML. Compared with NEML

WHO-EMLc and other 19 national essential medicines lists added the oral solution in children

and some countries indicated the age limit of chlorpheniramine and cetirizine. The dosage forms of anti-allergic drugs included in the lists were mainly ordinary tablets. Granules

syrups for children and other special formulations were listed

yet there were few manufacturers. Conclusion: Based on NEML and WHO-EMLc

and drawing on the experience of Sweden

Malaysia

Maldives and other countries

it is recommended to appropriately increase the dosage forms and specifications of second-generation antihistamines suitable for children

so as to to ensure the safety and effectiveness of clinical use in children and improve the national essential medicines list

关键词

基本药物基本药物目录抗变态反应药物儿童适宜性

Keywords

essential drugsnational essential medicines listanti-allergic drugschildrensuitability

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