Objective: To explore the prognosis of children with explosive myocarditis (FM) and analyze the risk factors affecting the prognosis of FM. Methods: Clinical data of children diagnosed with FM in Hunan Children’s Hospital from 2014 to 2020 were retrospectively analyzed. According to the survival status during hospitalization and follow-up

all children were divided into the survival group and the death group. The general data

clinical symptoms and related laboratory indicators were collected and followed up. The relevant factors affecting prognosis were screened for univariate analysis and multivariate Logistic regression analysis. Results: A total of 61 children with FM were collected

and there were 30 cases (49.2%) with pathogenic infections based on respiratory and enteroviruses. Totally 24 cases (39.3%) were onset with gastrointestinal symptoms

19 cases (31.3%) with respiratory symptoms

7 cases (11.5%) with neurological symptoms

and 11 cases (18.0%) with circulatory system symptoms. There were 52 cases (85.2%) in the survival group

including 7 cases (11.5%) with hypocardiac function and heart enlargement

and 9 cases (14.8%) in the death group. The main arrhythmia in the survival group was third-degree atrioventricular block

and the main arrhythmia in the death group was ventricular tachycardia. Univariate analysis showed that onset time

length of stay

creatine kinase (CK)

kinase isoenzyme (CK-MB)

and high-sensitivity troponin were factors that may affect the prognosis of children with FM. Multivariate Logistic regression analysis showed that there were significant differences in the onset time and high-sensitivity troponin. Conclusion: The shorter the onset time of FM and the higher the high-sensitivity troponin

the worse the prognosis may be.