Compatibility Stability of Cefoperazone Sodium/Sulbactam Sodium with Electrolyte Supplements Injection in Children

Ma Ailing; Zhao Ningmin; Du Yunfeng; Liu Mingzhou; Ma Peizhi; Zhang Wei

doi:10.13407/j.cnki.jpp.1672-108X.2022.09.004

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Compatibility Stability of Cefoperazone Sodium/Sulbactam Sodium with Electrolyte Supplements Injection in Children

更新时间：2022-11-04

- Compatibility Stability of Cefoperazone Sodium/Sulbactam Sodium with Electrolyte Supplements Injection in Children
- Vol. 28, Issue 9, Pages: 14-16(2022)
- 作者机构：
  
  河南省人民医院，郑州大学人民医院,郑州,450003
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.09.004
  CLC：
- Published：2022，
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Ma Ailing, Zhao Ningmin, Du Yunfeng, et al. Compatibility Stability of Cefoperazone Sodium/Sulbactam Sodium with Electrolyte Supplements Injection in Children. [J]. 28(9):14-16(2022)
DOI：

Ma Ailing, Zhao Ningmin, Du Yunfeng, et al. Compatibility Stability of Cefoperazone Sodium/Sulbactam Sodium with Electrolyte Supplements Injection in Children. [J]. 28(9):14-16(2022) DOI： 10.13407/j.cnki.jpp.1672-108X.2022.09.004.

摘要

目的：建立同时测定头孢哌酮钠与舒巴坦钠含量的高效液相色谱法，并考察头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液的配伍稳定性。方法：室温下观察24 h内配伍溶液的外观、pH、不溶性微粒，采用高效液相色谱法测定配伍溶液中头孢哌酮钠和舒巴坦钠的含量。结果：头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍后，24 h内配伍溶液的外观、pH值均无显著变化，不溶性微粒符合《中国药典》2015版规定，药物含量无明显变化。结论：头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍后24 h内稳定，临床可配伍使用。

Abstract

Objective: To establish the high performance liquid chromatography method for simultaneous determination of cefoperazone sodium and sulbactam sodium

and to investigate the compatibility stability of cefoperazone sodium and sulbactam sodium with electrolyte supplements injection in children. Methods: The appearance

pH and insoluble particle of the compatibility solution were observed at home temperature within 24 h. The contents of cefoperazone sodium and sulbactam sodium were determined by high performance liquid chromatography. Results: After the compatibility of cefoperazone sodium/sulbactam sodium with electrolyte supplements injection

the appearance and pH of the solution did not change significantly within 24 h. The insoluble particles were in accordance with the Chinese Pharmacopoeia (2015 Edition)

and the drug content did not change significantly. Conclusion: The compatibility solution of cefoperazone sodium/sulbactam sodium with electrolyte supplements injection in children is stable within 24 h

and can be used clinically.

关键词

头孢哌酮钠舒巴坦钠小儿电解质补给注射液配伍稳定性高效液相色谱法

Keywords

cefoperazone sodiumsulbactam sodiumelectrolyte supplements injection in childrencompatibility stabilityhigh performance liquid chromatography

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