Objective: To compare the effects of different doses of alfentanil hydrochloride induction on anesthesia effects and recovery quality in children undergoing bronchoscopy

so as to find the optimized dose of alfentanil induction. Methods: A total of 120 children aged from 1 to 3 years undergoing pediatric bronchoscopy under laryngeal mask general anesthesia were randomly divided into group A

B

C and D

with 30 cases in each group. Group A

B and C were induced by intravenous general anesthesia induction of alfentanil hydrochloride + atracurium cisbenesulfate injection 0.2 mg/kg+ propofol 2 mg/kg. The induction doses of alfentanil hydrochloride in group A

B

and C were respectively 30 μg/kg

40 μg/kg

and 50 μg/kg. Propofol 2 mg/kg was used to maintain anesthesia in each group. Group D was treated with intravenous general anesthesia induction of fentanyl citrate 2 mg/kg + atracurium cisbenesulfate injection 0.2 mg/kg + propofol 2 mg/kg. Changes of mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction (T0)

after intubation (T1)

at the beginning of surgery (T2) and at the time of extubation (T3). The surgery time

respiratory recovery time and extubation time of four groups were recorded. The sedation score standard of Wisconsin children’s Hospital in the United States (CHW sedation score) after extubation was recorded. Results: There were no significant differences in MAP and HR levels among four groups at T0 and T3 (P>0.05)

and MAP and HR levels in group A were higher than those in group B

C and D at T1 and T2 (P<0.05). The respiratory recovery time and extubation time of group A and B were shorter than those of group C and D (P<0.05). There were statistically significant differences in CHW sedation scores among four groups

and group B had the highest sedation satisfaction (from 3 to 5 points) after extubation (χ2=6.000

P<0.05). Conclusion: The intravenous induction dose of 40 mg/kg alfentanil hydrochloride for laryngeal mask general anesthesia in 13-year-old children undergoing bronchoscopy has better anesthesia effects and quality of recovery

which is worthy of clinical promotion