Investigation and Analysis on Off-Label Drug Use in Pediatric Outpatients of a Hospital

Liu Ting; Yu Jingjie

doi:10.13407/j.cnki.jpp.1672-108X.2022.05.007

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Investigation and Analysis on Off-Label Drug Use in Pediatric Outpatients of a Hospital

更新时间：2022-06-10

- Investigation and Analysis on Off-Label Drug Use in Pediatric Outpatients of a Hospital
- Vol. 28, Issue 5, Pages: 25-28(2022)
- 作者机构：
  
  西安交通大学第二附属医院,西安,710004
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.05.007
  CLC：
- Published：2022，
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Liu Ting, Yu Jingjie. Investigation and Analysis on Off-Label Drug Use in Pediatric Outpatients of a Hospital. [J]. 28(5):25-28(2022)
DOI：

Liu Ting, Yu Jingjie. Investigation and Analysis on Off-Label Drug Use in Pediatric Outpatients of a Hospital. [J]. 28(5):25-28(2022) DOI： 10.13407/j.cnki.jpp.1672-108X.2022.05.007.

摘要

目的：调查分析儿科门诊超说明书用药情况，为儿科合理用药提供参考。方法：随机抽取我院2019年7-12月儿科门诊处方，根据药品说明书判断其用药是否超说明书，统计分析超说明书用药类型、患儿年龄段及药品种类分布情况。结果：共抽取门诊处方1 200张，含3 285条用药医嘱。超说明书用药处方比例为29.42%，超说明书用药医嘱比例为18.60%。超说明用药类型主要是无儿童用药信息（45.17%）和超适应证用药（24.39%）。超说明书用药主要发生在婴幼儿期（32.25%）和学龄前期（21.27%），药物类别以呼吸系统用药（27.17%）、中成药（24.01%）和抗感染药（22.92%）为主。结论：儿科门诊超说明用药较普遍，国家应制定相关法规，医院应加强超说明书用药的监管，以保障儿童用药的安全合理。

Abstract

Objective: To investigate and analyze the off-label drug use in the pediatric outpatients

so as to provide reference for rational drug use in pediatrics. Methods: Pediatric outpatient prescriptions in our hospital from Jul. to Dec. 2019 were randomly extracted to determine whether off-label drug use was used according to drug instructions

and the types of off-label drug use

age of children and distribution of drug types were statistically analyzed. Results: A total of 1

200 outpatient prescriptions were selected

including 3

285 medical orders. The proportion of off-label drug use prescriptions was 29.42%

and the proportion of off-label drug use medical orders was 18.60%. The main types of off-label drug use were no information on drug use for children (45.17%) and off-label indication (24.39%). Off-label drug use mainly occurred in infancy (32.25%) and preschool age (21.27%)

and the drug categories were mainly respiratory system drugs (27.17%)

Chinese patent medicines (24.01%) and anti-infective drugs (22.92%). Conclusion: Off-label drug use is common in pediatric outpatients

relevant laws and regulations should be formulated and supervision of off-label drug use should be strengthened in hospitals to ensure the safety and rationality of drug use in children.

关键词

儿科超说明书合理用药

Keywords

pediatricsoff-labelrational drug use

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