Investigation and Analysis of Off-Label Drug Use Prescriptions of Microecological Preparations in Pediatric Clinics

Liu Yajuan; Liu Xin; Cao Yidan

doi:10.13407/j.cnki.jpp.1672-108X.2022.03.009

您当前的位置：

首页 >

文章列表页 >

Investigation and Analysis of Off-Label Drug Use Prescriptions of Microecological Preparations in Pediatric Clinics

更新时间：2022-11-03

- Investigation and Analysis of Off-Label Drug Use Prescriptions of Microecological Preparations in Pediatric Clinics
- Vol. 28, Issue 3, Pages: 30-33(2022)
- 作者机构：
  
  吉林大学第一医院,长春,130021
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.03.009
  CLC：
- Published：2022，
  
  Published Online：10 March 2022，
扫描看全文
Liu Yajuan, Liu Xin, Cao Yidan. Investigation and Analysis of Off-Label Drug Use Prescriptions of Microecological Preparations in Pediatric Clinics. [J]. 28(3):30-33(2022)
DOI：

Liu Yajuan, Liu Xin, Cao Yidan. Investigation and Analysis of Off-Label Drug Use Prescriptions of Microecological Preparations in Pediatric Clinics. [J]. 28(3):30-33(2022) DOI： 10.13407/j.cnki.jpp.1672-108X.2022.03.009.

摘要

目的：了解吉林大学第一医院儿科门诊微生态制剂使用现状及存在的问题。方法：通过医院信息系统（HIS）调取我院2019年1-12月儿科门诊使用微生态制剂处方。参照药品说明书，对患儿的基本信息、微生态制剂使用品种及超说明书用药情况进行统计分析。结果：共抽取含微生态制剂处方10 372张，涉及品种包括布拉氏酵母菌活菌制剂（2 580张，24.87%）、酪酸梭菌肠球菌三联活菌片（2 648张，25.53%）、酪酸梭菌活菌散（4 564张，44.01%）、双歧杆菌三联活菌肠溶胶囊（144张，1.39%）及双歧杆菌四联活菌片（436张，4.2%）；微生态制剂超说明书用药主要表现为超适应证用药（6 272张，60.47%）、超用法用量用药（4 504张，43.42%）及超适应人群用药（450张，4.34%）。结论：微生态制剂在儿科用药中超说明书用药的比例较高，应规范医务人员的处方行为。此外，国家相关部门应敦促药品生产企业及时完善修订微生态制剂药品说明书中儿童用药的相关信息，以保障患儿用药的合理性和安全性

Abstract

Objective: To investigate the current status and problems of microecological preparations in the pediatric clinics of the First Hospital of Jilin University. Methods: Prescription of microecological preparations in the pediatric clinics of our hospital from Jan. to Dec. 2019 was retrieved through the hospital information system (HIS). The general information

varieties of microecological preparations and off-label drug use were statistically analyzed according to the drug instructions. Results: A total of 10

372 prescriptions of microecological preparations were extracted

including Saccharomyces boulardii preparations (2

580 pieces

24.87%)

triple live bacteria of Clostridium butyricum enterococcus triple viable bacterial tablet (2

648 pieces

25.53%)

Clostridium typhimurium powders (4

564 pieces

44.01%)

Bifidobacterium triplet enteric-coated capsules (144 pieces

1.39%) and Bifidobacterium quadruple live bacteria (436 pieces

4.2%). Off-label use of microecological preparations mainly included off-label indications (6

272 pieces

60.47%)

off-label usage and dosage (4

504 pieces

43.42%) and off-label adaptation population (450 pieces

4.34%). Conclusion: Microecological preparations have a higher percentage of off-label use in pediatric medicines

and the prescription behavior of medical personnel should be standardized. Meanwhile

relevant national departments should inspire the drug manufacturers to complete and revise the relevant information on children’s medication in the drug instructions of microecological preparations in a timely manner

so as to ensure the rationality and safety of medication for children

关键词

微生态制剂儿科门诊超说明书用药

Keywords

microecological preparationspediatric clinicsoff-label drug use

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Investigation of Off-Label Drug Use of Pediatric Microecological Preparations in China

Meta-Analysis on Efficacy of Triple Therapy Combined with Synbiotics in Eradication of Helicobacter Pylor

Systematic Review of Off-Label Drug Use in Hospitalized Neonates

Investigation of Off-Label Drug Use in Pediatrics of a Hospital in 2017

Investigation of Off-Label Drug Use in Pediatric Outpatient Department of Our Hospital in 2017

Related Author

Zhao Zhichao

Wang Xiaoling

Zhang Li

Wei Ting

Jin Yan

Deng Chun

Luo Xuan

Deng Juan

Related Institution

Beijing Children’s Hospital, Capital Medical University

Harbin Children’s Hospital

Yongchuan Hospital of Chongqing Medical University

Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics

Shanghai Fengxian District Fengcheng Hospital

⁰