Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital

Wang Fengjiao; Yao Hua; Yan Yinghui

doi:10.13407/j.cnki.jpp.1672-108X.2022.03.006

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Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital

更新时间：2022-11-03

- Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital
- Vol. 28, Issue 3, Pages: 20-23(2022)
- 作者机构：
  
  苏州大学附属儿童医院,江苏,苏州,215025
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.03.006
  CLC：
- Published：2022，
  
  Published Online：10 March 2022，
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Wang Fengjiao, Yao Hua, Yan Yinghui. Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital. [J]. 28(3):20-23(2022)
DOI：

Wang Fengjiao, Yao Hua, Yan Yinghui. Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital. [J]. 28(3):20-23(2022) DOI： 10.13407/j.cnki.jpp.1672-108X.2022.03.006.

摘要

目的：探讨某儿童医院严重药品不良反应（ADR）发生特点和规律，为临床合理用药提供参考。方法：收集我院2017-2019年上报的严重ADR报告，对患儿年龄、性别、给药途径、药品种类等相关因素进行统计分析。结果：132例严重ADR中，男85例（64.39%），女47例（35.61%）。121例严重ADR给药途径为静脉用药，10例为口服给药，1例为喷雾剂。132例严重ADR中抗感染药物占比（47.73%）最高，其次为糖皮质激素（9.09%）、维生素类及营养支持类（6.06%）和中药注射剂（6.06%）。132例严重ADR主要累及皮肤及其附件损害，其次为全身性损害。结论：临床应重视儿童严重ADR的监测和报告，尤其是抗感染药物、糖皮质激素、辅助用药和中药注射剂，进一步规范儿童安全合理用药

Abstract

Objective: To investigate the characteristics and rules of severe adverse drug reactions (ADR) in a children’s hospital

so as to promote the rational drug use in the clinic. Methods: Severe ADR reported in the hospital from 2017 to 2019 were collected

and related factors such as age

gender

route of administration and drug categories were statistically analyzed. Results: Of the 132 cases of severe ADR

85 cases were males (64.39%) and 47 cases were females (35.61%). The route of administration in 121 cases of severe ADR was intravenous administration

10 cases were oral administration

and 1 case was spray. Among the 132 cases of severe ADR

anti-infective drugs accounted for the highest proportion (47.73%)

followed by glucocorticoids (9.09%)

vitamins and nutritional support drugs (6.06%)

and traditional Chinese medicine injections (6.06%). One hundred and thirty-two cases of severe ADR mainly involved skin and its accessory damage

followed by systemic damage. Conclusion: Clinical attention should be paid to the monitoring and reporting of severe ADR in children

especially anti-infective drugs

glucocorticoids

vitamins and nutritional support drugs and traditional Chinese medicine injections

so as to further standardize the safe and rational drug use in children

关键词

不良反应儿童合理用药

Keywords

adverse drug reactionschildrenrational drug use

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