Objective: To investigate the results of sputum culture and drug sensitivity test in children with congenital heart disease complicated with pulmonary infection in our hospital

so as to provide reference for early rational drug use in children. Methods: A total of 372 children with congenital heart disease complicated with pulmonary infection

aged (1.5±0.5) years

admitted into our hospital from Jan. 2014 to Aug. 2018 were retrospectively analyzed. The deep tracheal sputum was absorbed through the sterile sputum suction tube on admission and sent to the clinical laboratory for sputum culture and drug sensitivity test. The results of sputum culture and drug sensitivity test were statistically analyzed. Results: The positive rate of pathogenic bacteria in sputum culture was 48.7% (181/372)

and 27 kinds of pathogenic bacteria were detected

including 16 kinds of G- bacteria

6 kinds of G+ bacteria and 5 kinds of fungi. Escherichia coli and Klebsiella pneumoniae were the most common strains of G- bacteria

while Staphylococcus aureus and Streptococcus pneumoniae were the most common strains of G+ bacteria. Drug sensitivity test indicated that the main pathogens were more sensitive to carbapenems

the third generation cephalosporins and fluoroquinolones

but less sensitive to penicillins

the first generation cephalosporins and the second generation cephalosporins. S. aureus was sensitive to vancomycin

linezolid

the third generation cephalosporins and quinolones

and had a high drug resistance rate to penicillin. Conclusion: The sputum culture of children with congenital heart disease complicated with pulmonary infection is dominated by G- bacteria

and the bacteria are highly sensitive to the third generation cephalosporins. The third generation cephalosporins can be empirically preferred before the results of the drug sensitivity test are clear

followed by carbapenems as appropriate

and quinolones if necessary; if the sputum culture results are Staphylococcus aureus infection

linezolid can be preferre