Protective Effects of Nalmephen Hydrochloride on Nervous System after Cardiopulmonary Resuscitation in Children

Li Mu; Han Meilin; Dai Yunhong; Pu Xiangqiang; Dong Xingqiang; Shi Chujin; Li Ying

doi:10.13407/j.cnki.jpp.1672-108X.2021.12.003

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Protective Effects of Nalmephen Hydrochloride on Nervous System after Cardiopulmonary Resuscitation in Children

更新时间：2022-11-03

- Protective Effects of Nalmephen Hydrochloride on Nervous System after Cardiopulmonary Resuscitation in Children
- Vol. 27, Issue 12, Pages: 10-13(2021)
- 作者机构：
  
  苏州大学附属儿童医院,江苏,苏州,215000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.12.003
  CLC：
- Published：2021，
  
  Published Online：10 December 2021，
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Li Mu, Han Meilin, Dai Yunhong, et al. Protective Effects of Nalmephen Hydrochloride on Nervous System after Cardiopulmonary Resuscitation in Children. [J]. 27(12):10-13(2021)
DOI：

Li Mu, Han Meilin, Dai Yunhong, et al. Protective Effects of Nalmephen Hydrochloride on Nervous System after Cardiopulmonary Resuscitation in Children. [J]. 27(12):10-13(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.12.003.

摘要

目的：研究心肺复苏后患儿应用盐酸纳美芬血清中强啡肽的变化，评估盐酸纳美芬对儿童心肺复苏后神经系统损伤的保护作用及其不良反应。方法：选取心肺复苏后患儿40例，随机数字表法分为治疗组和对照组各20例。对照组采用降颅压、抗感染、营养神经等常规治疗；治疗组在常规治疗的基础上加用盐酸纳美芬治疗。所有患儿在治疗前及治疗后第1、3、7天测定血清强啡肽的含量，同时记录患儿心率、呼吸变化及药物不良反应，对比两组患儿1个月后的格拉斯哥昏迷评分（GCS）。结果：治疗前治疗组患儿血清强啡肽含量（915.45±195.63）pg/mL，对照组患儿血清强啡肽含量（962.32±220.71）pg/mL，两组比较差异无统计学意义；治疗后两组患儿血清强啡肽含量均呈下降趋势，治疗后第1天治疗组血清强啡肽含量（807.06±155.90）pg/mL，对照组血清强啡肽含量（1 105.04±224.79）pg/mL，差异有统计学意义（P<0.001），治疗后第3天和第7天治疗组血清强啡肽含量与对照组比较差异无统计学意义(P>0.05)。治疗组的呼吸异常、心率异常发生率均比对照组低，且治疗组心率异常的发生率低于对照组（P<0.05）；两组治疗过程中药物不良反应发生率比较差异无统计学意义（P>0.05）。治疗组临床症状、体征、脑部影像学及脑电图改善情况均优于对照组。结论：盐酸纳美芬可降低心肺复苏后患儿血清强啡肽水平，能减轻继发性颅脑损伤，对神经系统具有一定的保护作用，同时可降低心肺复苏后患儿心率异常发生率。

Abstract

Objective: To study the variation of serum dynorphin after the treatment of nalmephen hydrochloride in children after cardiopulmonary resuscitation

and to evaluate the protective effects of nalmephen hydrochloride on neurological injury after cardiopulmonary resuscitation and its adverse drug reactions. Methods: Forty children with cardiopulmonary resuscitation were extracted to be divided into the treatment group and the control group via the random number table

with 20 cases in each group. The control group received conventional treatment such as intracranial pressure reducing

anti-infection and nerve nutrition; the treatment group was treated with nalmefene hydrochloride on the basis of conventional treatment. Serum level of dynorphin was measured in all children before treatment and on the 1st

3rd and 7th d after treatment

and changes in heart rate

respiration and adverse drug reactions were recorded. Glasgow Coma scale (GCS) was compared between two groups after treatment of 1 month. Results: Before treatment

the serum level of dynorphin in the treatment group was (915.45±195.63) pg/mL

and the serum level of dynorphin in the control group was (962.32±220.71) pg/mL

with no statistically significant difference between two groups. After treatment

the serum level of dynorphin in two groups showed the downward trend. On the 1st d after treatment

the serum level of dynorphin in the treatment group was (807.06±155.90) pg/mL

and the serum level of dynorphin in the control group was (1

105.04±224.79) pg/mL

the difference was statistically significant (P<0.01). There was no significant difference in the serum level of dynorphin between two groups on the 3rd and 7th d after treatment (P>0.05). The incidence of respiratory abnormalities and heart rate abnormalities were lower in the treatment group than in the control group

and the incidence of heart rate abnormalities was lower in the treatment group than in the control group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). The improvements of clinical symptoms

signs

brain imaging and EEG in the treatment group were better than those in the control group. Conclusion: Nalmephen hydrochloride can reduce the serum level of dynorphin in children after cardiopulmonary resuscitation

relieve the secondary craniocerebral injury

protect the nervous system

and reduce the incidence of abnormal heart rate in children after cardiopulmonary resuscitation.

关键词

盐酸纳美芬心肺复苏儿童神经系统

Keywords

nalmephen hydrochloridecardiopulmonary resuscitationchildrennervous system

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