Clinical Efficacy of Nasal Duo Positive Airway Pressure Combined with Less Invasive Pulmonary Surfactant Administration Technique in the Treatment of Premature Infants with Respiratory Distress Syndrome

Liu Yanhong; Liang Guijuan; Jia Meiyun; Li Yuanzheng; Kang Jianing; Zhang Huimin; Yan Anping

doi:10.13407/j.cnki.jpp.1672-108X.2021.12.002

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Clinical Efficacy of Nasal Duo Positive Airway Pressure Combined with Less Invasive Pulmonary Surfactant Administration Technique in the Treatment of Premature Infants with Respiratory Distress Syndrome

更新时间：2022-11-03

- Clinical Efficacy of Nasal Duo Positive Airway Pressure Combined with Less Invasive Pulmonary Surfactant Administration Technique in the Treatment of Premature Infants with Respiratory Distress Syndrome
- Vol. 27, Issue 12, Pages: 6-9(2021)
- 作者机构：
  
  郑州人民医院,河南,郑州,450000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.12.002
  CLC：
- Published：2021，
  
  Published Online：10 December 2021，
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Liu Yanhong, Liang Guijuan, Jia Meiyun, et al. Clinical Efficacy of Nasal Duo Positive Airway Pressure Combined with Less Invasive Pulmonary Surfactant Administration Technique in the Treatment of Premature Infants with Respiratory Distress Syndrome. [J]. 27(12):6-9(2021)
DOI：

Liu Yanhong, Liang Guijuan, Jia Meiyun, et al. Clinical Efficacy of Nasal Duo Positive Airway Pressure Combined with Less Invasive Pulmonary Surfactant Administration Technique in the Treatment of Premature Infants with Respiratory Distress Syndrome. [J]. 27(12):6-9(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.12.002.

摘要

目的：探讨经鼻双水平正压通气联合不同时间点经细管肺表面活性物质(PS)注入技术（LISA）治疗早产儿呼吸窘迫综合征（RDS）的临床疗效。方法：选取2017年6月至2018年6月郑州人民医院收治的RDS早产儿58例，按随机数表法分为早期LISA组（n=30）及补救性LISA组（n=28）。早期LISA组给予DuoPAP辅助呼吸，将胃管置入气管内，PS缓慢经胃管注入，注入时由DuoPAP辅助呼吸，注入完毕后拔出胃管，继续DuoPAP辅助呼吸；补救性LISA组患儿给予DuoPAP辅助呼吸，若出现进行性加重呼吸困难，将胃管置入气管内，补救性将PS缓慢经胃管注入，注入完毕后拔出胃管，继续DuoPAP辅助呼吸，比较两组患儿需要机械通气的比例、住院时间、住院费用，记录气胸、肺炎、支气管肺发育不良（BPD）和颅内出血（ICH）发生率。结果：两组患儿机械通气需求比例、无创通气时间、肺炎发生率、住院时间、气胸、BPD及ICH发生率等比较差异无统计学意义（P>0.05）。补救性LISA组住院费用低于早期LISA组，差异有统计学意义（P<0.05）。结论：采用经鼻双水平正压通气联合补救性LISA技术可有效缓解呼吸窘迫，降低住院费用，且未增加气漏、支气管肺发育不良、颅内出血发生率，未延长住院时间

Abstract

To probe into the clinical efficacy of nasal duo positive airway pressure (DuoPAP) combined with less invasive pulmonary surfactant (PS) administration (LISA) technique at different time points in the treatment of premature infants with respiratory distress syndrome (RDS). Methods: A total of 58 premature infants with RDS admitted into Zhengzhou People’s Hospital from Jun. 2017 to Jun. 2018 were extracted to be divided into the early LISA group (n=30) and the remedial LISA group (n=28) via the random number table. In the early LISA group

DuoPAP was given

the gastric tube was placed into the trachea

PS was slowly injected through the gastric tube

DuoPAP was given during the injection

and the gastric tube was removed and DuoPAP was continued after the injection was completed. Children in the remedial LISA group were given DuoPAP

if progressive worsening dyspnea occurred

the gastric tube was placed into the trachea

and PS was slowly injected through the gastric tube remedially

and the gastric tube was removed and DuoPAP was continued after the injection was completed. The proportion of children requiring mechanical ventilation

length of stay and hospitalization costs were compared between two groups

and the incidences of pneumothorax

pneumonia

bronchopulmonary dysplasia (BPD) and intracranial hemorrhage (ICH) were recorded. Results: There were no statistically significant differences between two groups in the proportion of children requiring mechanical ventilation

duration of noninvasive ventilation

incidence of pneumonia

length of stay

incidence of pneumothorax

BPD and ICH (P>0.05). The hospitalization costs of the remedial LISA group were lower than those of the early LISA group

the difference was statistically significant (P<0.05). Conclusion: DuoPAP combined with LISA technique can effectively relieve the respiratory distress

reduce the hospitalization costs

and do not increase the incidence of air leakage

BPD

intracranial hemorrhage

and prolong the length of stay.

关键词

微创注入肺表面活性物质治疗技术呼吸窘迫综合征早产儿

Keywords

less invasive pulmonary surfactant administration techniquerespiratory distress syndromepremature infants

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