Investigation of Off-Label Drug Use in Pediatric Intensive Care Unit

Zhao Kai; Tian Zhen; Zhao Fang; Shen Yixuan; Li Siwei; Chang Ying

doi:10.13407/j.cnki.jpp.1672-108X.2021.10.009

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Investigation of Off-Label Drug Use in Pediatric Intensive Care Unit

更新时间：2022-11-03

- Investigation of Off-Label Drug Use in Pediatric Intensive Care Unit
- Vol. 27, Issue 10, Pages: 28-32(2021)
- 作者机构：
  
  1. 广州市妇女儿童医疗中心,广东,广州,510623
  2. 西北妇女儿童医院,陕西,西安,710061
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.10.009
  CLC：
- Published：2021，
  
  Published Online：10 October 2021，
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Zhao Kai, Tian Zhen, Zhao Fang, et al. Investigation of Off-Label Drug Use in Pediatric Intensive Care Unit. [J]. 27(10):28-32(2021)
DOI：

Zhao Kai, Tian Zhen, Zhao Fang, et al. Investigation of Off-Label Drug Use in Pediatric Intensive Care Unit. [J]. 27(10):28-32(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.10.009.

摘要

目的：调查儿童重症患者超说明书用药现状，分析可能的超说明书用药危险因素，为促进儿科重症监护病区合理用药提供参考。方法：分层随机抽取西北妇女儿童医院2019年儿科重症监护病区的医嘱，根据药品说明书，判断是否超说明书用药。分析不同年龄段、不同科室、不同级别医师、不同种类药品的超说明书用药发生率。分析超说明书用药与患儿基本信息（年龄、性别）、医师级别和药品信息（基本药物、高警示药物）的相关性。结果：共纳入患儿864例，医嘱13 926条，药品200种，超说明书用药发生率分别为87.27%、53.02%和56.00%。新生儿、女性患儿、高职称医师、基本药物、高警示药物存在较高的超说明书用药风险（P<0.05）。结论：儿童重症患者超说明书用药情况普遍存在，新生儿、女性患儿、高职称医师、基本药物、高警示药物为超说明用药的危险因素。药师需发挥用药指导作用，协助医师规避用药风险，促进重症患儿安全合理用药。

Abstract

Objective: To investigate the application status of off-label drug use in children from pediatric intensive care unit (PICU)

and to analyze the risk factors of off-label drug use

so as to provide reference for promoting the rational drug use in PICU. Methods: Medical orders were selected from the PICU of Northwest Women’s and Children’s Hospital in 2019 through the proportionate stratified random sampling method

and off-label drug use was judged according to the drug instructions. The incidences of off-label drug use in different age groups

departments

levels of clinicians and different kinds of drugs were analyzed. Correlation between off-label drug use and children’s basic information (age

gender)

levels of clinicians and drug information (essential drugs

high-alert drugs) was analyzed. Results: A total of 864 children were enrolled

including 13

926 medical orders and 200 kinds of drugs. The incidence of off-label drug use was respectively 87.27%

53.02% and 56.00%. Newborns

female children

clinicians with high professional titles

essential drugs and high-alert drugs had higher risks of off-label drug use (P<0.05). Conclusion: Off-label drug use is widespread in children from PICU. Newborns

female children

clinicians with high professional titles

essential drugs and high-alert drugs are risk factors of off-label drug use. Pharmacists are supposed to play a role in guiding rational drug use

assisting clinicians in avoiding drug use risks and promoting the safe and rational drug use in critically ill children.

关键词

儿科重症监护病区超说明书用药危险因素分析

Keywords

pediatricsntensive care unitoff-label drug userisk factors analysis

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Related Author

Shen Yixuan

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Li Siwei

Chang Ying

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Wang Xiaoling

Zhang Li

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Related Institution

Northwest Women and Children’s Hospital

Beijing Children’s Hospital, Capital Medical University

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National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University

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