Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children

Xu Dongya; Li Yanhong; Liu Jiaxin; Du Qipeng

doi:10.13407/j.cnki.jpp.1672-108X.2021.10.007

您当前的位置：

首页 >

文章列表页 >

Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children

更新时间：2022-11-03

- Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children
- Vol. 27, Issue 10, Pages: 21-24(2021)
- 作者机构：
  
  广州中医药大学附属广东中西医结合医院,广东,佛山,528200
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.10.007
  CLC：
- Published：2021，
  
  Published Online：10 October 2021，
扫描看全文
Xu Dongya, Li Yanhong, Liu Jiaxin, et al. Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children. [J]. 27(10):21-24(2021)
DOI：

Xu Dongya, Li Yanhong, Liu Jiaxin, et al. Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children. [J]. 27(10):21-24(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.10.007.

摘要

目的：探讨阿奇霉素辅助治疗儿童变应性鼻炎引起的上气道咳嗽综合征（UACS）的有效性及安全性，并进一步研究其有效机制。方法：采用随机、开放、单盲、平行对照试验方法，选取2013年4月至2019年4月我院儿科门诊诊断为变应性鼻炎引起的UACS患儿140例，随机分为治疗组和对照组各70例。两组患儿均采用口服孟鲁司特钠联合糠酸莫米松鼻喷雾剂疗法，在此基础上，治疗组加用口服阿奇霉素，对照组加用口服安慰剂。结果：治疗10 d后，两组患儿咳嗽症状积分和视觉模拟评分均明显改善（P<0.05），治疗组改善情况优于对照组（P<0.01）；治疗组总有效率高于对照组（P<0.05）。治疗14 d后，两组一氧化氮、肿瘤坏死因子-α和血清总免疫球蛋白E水平均明显改善（P<0.01），治疗组改善情况优于对照组（P<0.01）。治疗过程中，部分患儿（1.42%）出现轻度胃肠道反应，未见其他不良反应，治疗结束后两组患儿血常规、肝肾功能均未见异常。结论：阿奇霉素治疗儿童变应性鼻炎引起的UACS有一定疗效，安全性高，其机制可能与抗炎、免疫调节作用有关。

Abstract

Objective: To probe into the efficacy and safety of azithromycin in the adjuvant treatment of upper airway cough syndrome (UACS) induced by allergic rhinitis in children

and to further study the effective mechanism. Methods: By using the method of random

open

single-blind and parallel controlled trial

140 children diagnosed with UACS induced by allergic rhinitis in the pediatric outpatient department of our hospital from Apr. 2013 to Apr. 2019 were extracted to be randomly divided into the treatment group and the control group

with 70 cases in each group. Both groups were treated with oral montelukast sodium combined with mometasone furoate nasal spray. On this basis

the treatment group received oral azithromycin

while the control group was given oral placebo. Results: After treatment of 10 d

the scores of cough symptom and visual analogue scale of two groups were significantly improved (P<0.05)

and the improvement of the treatment group was better than that of the control group (P<0.01). The total effective rate in the treatment group was higher than that in the control group (P<0.05). After treatment of 14 d

the levels of nitric oxide

tumor necrosis factor-α and serum total immunoglobulin E were significantly improved in both groups (P<0.01)

and the improvement in the treatment group was better than that in the control group (P<0.01). During the treatment

some children (1.42%) had mild gastrointestinal reactions

no other adverse drug reactions were observed

and no abnormalities in blood routine

liver and kidney function were observed in both groups at the end of treatment. Conclusion: Azithromycin is effective and safe in the treatment of UACS induced by allergic rhinitis in children. Its mechanism may be related to anti-inflammatory and immunomodulatory effects.

关键词

阿奇霉素儿童变应性鼻炎上气道咳嗽综合征随机对照试验

Keywords

azithromycinchildrenallergic rhinitisupper airway cough syndromerandomized controlled trial

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Cardiovascular Adverse Drug Reactions Induced by Azithromycin Injection in Children

Systematic Review and Meta-Analysis on Efficacy of Probiotics in Prevention of Children with Urinary Tract Infection

Application Value of Doxycycline in Children with Severe Mycoplasma Pneumoniae Pneumonia

Analysis of 36 Cases of Drug Poisoning in Children in a Grade III, Level A General Hospital andConsideration on Pharmaceutical Care

Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Related Author

Hu Jing

Wu Ziyong

Wang Wei

Qin Qin

Zhang Min

Xiang Hui

Tian Chao

Shi Qiang

Related Institution

Ezhou Central Hospital

Jingmen People’s Hospital

The Fifth Hospital of Huangshi

Huangshi Central Hospital, Edong Group, Affiliated Hospital of Hubei Institute of Technology

National Center for Chidren’s Health, Beijing Children’s Hospital, Capital Medical University

⁰