Effects of ε-Polylysine on Bacterial Colonization, Ventilator-Associated Pneumonia and Expression Levels of TNF-α and IL-6 in Children with Mechanical Ventilation

Dai Mina; Hu Peng; Zhang Liqin

doi:10.13407/j.cnki.jpp.1672-108X.2021.10.004

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Effects of ε-Polylysine on Bacterial Colonization, Ventilator-Associated Pneumonia and Expression Levels of TNF-α and IL-6 in Children with Mechanical Ventilation

更新时间：2022-11-03

- Effects of ε-Polylysine on Bacterial Colonization, Ventilator-Associated Pneumonia and Expression Levels of TNF-α and IL-6 in Children with Mechanical Ventilation
- Vol. 27, Issue 10, Pages: 12-15(2021)
- 作者机构：
  
  1. 浙江省杭州市萧山区中医院,浙江,杭州,311201
  2. 江苏省南通市妇幼保健院,江苏,南通,226000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.10.004
  CLC：
- Published：2021，
  
  Published Online：10 October 2021，
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Dai Mina, Hu Peng, Zhang Liqin. Effects of ε-Polylysine on Bacterial Colonization, Ventilator-Associated Pneumonia and Expression Levels of TNF-α and IL-6 in Children with Mechanical Ventilation. [J]. 27(10):12-15(2021)
DOI：

Dai Mina, Hu Peng, Zhang Liqin. Effects of ε-Polylysine on Bacterial Colonization, Ventilator-Associated Pneumonia and Expression Levels of TNF-α and IL-6 in Children with Mechanical Ventilation. [J]. 27(10):12-15(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.10.004.

摘要

目的：分析ε-聚赖氨酸对儿科机械通气患儿管路细菌定植、呼吸机相关性肺炎（VAP）发生情况及肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）表达水平的影响。方法：回顾性分析杭州市萧山区中医院2017年8月至2019年8月收治的60例机械通气患儿的临床资料，按照是否给予ε-聚赖氨酸干预分为观察组和对照组各30例，观察组给予ε-聚赖氨酸干预，对照组不做处理，观察并记录两组管路不同位置的细菌定植情况、VAP发生情况、机械通气时间、TNF-α及IL-6表达水平，然后进行对比分析。结果：上机第4天和第7天，对照组Y型接口处（66.67%、77.67%）及进气段（33.33%、66.67%）、出气段冷凝水部位（46.67%、80.00%）细菌阳性检出率均高于观察组（均为0%）（P<0.05）；观察组VAP发生率（10.00%）低于对照组（40.00%），机械通气时间（4.36±0.55）d，短于对照组（7.31±0.49）d（P<0.05）；观察组患儿上呼吸机后第4天和第7天的TNF-α（39.25±11.88、18.56±4.65）ng/mL及IL-6（29.38±8.33、20.05±9.48）pg/mL表达水平低于对照组（P<0.05）。结论：ε-聚赖氨酸干预法能够抑制儿科机械通气管路的细菌定植，降低VAP发生率，缩短机械通气时间

降低TNF-α及IL-6等免疫炎性反应因子。

Abstract

Objective: To analyze the effects of ε-polylysine on bacterial colonization

ventilator-associated pneumonia (VAP) and expression levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in children with mechanical ventilation. Methods: Clinical data of 60 children with mechanical ventilation admitted into Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine from Aug. 2017 to Aug. 2019 were retrospectively analyzed. According tor ε-polylysine intervention

all patients were divided into the observation group and the control group

with 30 cases in each group. The observation group was given ε-polylysine intervention

while the control group was left untreated. The bacterial colonization

occurrence of VAP

time of mechanical ventilation

expression levels of TNF-α and IL-6 at different positions of pipelines in two groups were observed

recorded and compared. Results: On the 4th and 7th d after ventilator

the positive bacterial detection rate in the control group at the Y-type junction (66.67% and 77.67%)

inlet section (33.33% and 66.67%) and condensate section (46.67% and 80.00%) was higher than that in the observation group (0% and 0%)

the difference was statistically significant (P<0.05). The incidence of VAP in the observation group (10.00%) was lower than that in the control group (40.00%)

and the time of mechanical ventilation in the observation group (4.36±0.55) d was shorter than that in the control group (7.31±0.49) d (P<0.05). The expression levels of TNF-α (39.25±11.88

18.56±4.65) ng/mL and IL-6 (29.38±8.33

20.05±9.48) pg/mL in the observation group were lower than those in the control group on the 4th and 7th d after ventilator (P<0.05). Conclusion: The ε-polylysine method can inhibit bacterial colonization of pediatric mechanical ventilation

reduce the incidence of VAP

shorten the time of mechanical ventilation

and decrease the levels of inflammatory factors such as TNF-α and IL-6.

关键词

呼吸机相关性肺炎儿科机械通气ε-聚赖氨酸干预法管路细菌定植血清炎症因子

Keywords

entilator-associated pneumoniapediatricsmechanical ventilationε-polylysine interventionbacterial colonizationserum inflammatory factors

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