Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children

Wang Yue; Ge Dongmei; Cheng Qian; Dai Ying

doi:10.13407/j.cnki.jpp.1672-108X.2021.07.001

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Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children

更新时间：2022-11-03

- Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children
- Vol. 27, Issue 7, Pages: 1-7(2021)
- 作者机构：
  
  重庆医科大学附属儿童医院，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.07.001
  CLC：
- Published：2021，
  
  Published Online：10 July 2021，
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Wang Yue, Ge Dongmei, Cheng Qian, et al. Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children. [J]. 27(7):1-7(2021)
DOI：

Wang Yue, Ge Dongmei, Cheng Qian, et al. Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children. [J]. 27(7):1-7(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.07.001.

摘要

目的：采用Meta分析的方法评估血清维生素D水平与儿童孤独症谱系障碍（ASD）的相关性。方法：计算机全面检索Medline、EMBase、PubMed、Scopus、the Cochrane Library、EBSCO、Web of Science、中国生物医学文献数据库（CBMdisc）、中国知网（CNKI）、万方数据库、维普网等电子数据库，收集有关与维生素D水平与儿童孤独症谱系障碍相关的病例对照研究进行Meta分析，以加权均数差（Weighted Mean Difference，WMD）及其95%CI为合并效应量，应用Review Manager 5.3及Stata 16软件进行Meta分析，并进行发表偏倚评估和敏感性分析。结果：共纳入14篇文献、2 403例参与者（1 135例ASD患儿和1 268例健康对照）。Meta分析结果显示，总体人群中ASD患者血清25-羟基维生素D[25-（OH）D]水平明显低于对照组（WMD=-8.91，95%CI：-12.45~-5.37，P<0.01）。亚组分析结果显示，中国人群中ASD患儿血清25-（OH）D水平明显低于对照组（WMD=-10.81，95%CI：-16.80~-4.82，P<0.01），中东人群中ASD患儿血清25-（OH）D水平明显低于对照组（WMD=-9.35，95%CI：-18.09~-0.60，P=0.04），欧美（不含中东国家）人群中ASD患儿血25-（OH）D水平与对照组比较差异无统计学意义（WMD=-6.22，95%CI：-12.87~0.44，P=0.07）。结论：维生素D缺乏可能是儿童孤独症谱系障碍的危险因素

Abstract

Objective: To evaluate the relationship between serum vitamin D levels and autism spectrum disorders (ASD) in children by Meta-analysis. Methods: Medline

EMBase

PubMed

Scopus

the Cochrane Library

EBSCO

Web of Science

CBMdisc

CNKI

Wanfang database and VIP database were retrieved to collect case-control studies related to vitamin D levels and ASD in children by Meta-analysis. Weighted mean difference (WMD) and 95% CI were used as the combined effect size

and Meta-analysis was performed by using Rev Man 5.3 and Stata 16.0 software. Publication bias assessment and sensitivity analysis were performed. Results: A total of 14 literature were collected

including 2

403 participants (1

135 children with ASD and 1

268 healthy controls). Meta-Analysis showed that serum 25-hydroxyvitamin D (25-(OH)D) level in children with ASD was significantly lower than that in the control group (WMD=-8.91

95%CI: from -12.45 to -5.37

P<0.01). The results of subgroup analysis showed that the serum 25-(OH)D level in children with ASD from China was significantly lower than that in the control group (WMD=-10.81

95%CI: from -16.80 to -4.82

P<0.01)

the serum 25-(OH)D level in children with ASD from the Middle East was significantly lower than that in the control group (WMD=-9.35

95%CI: from -18.09 to -0.60

P=0.04). In European and American countries (except for the Middle East countries)

there was no significant difference in serum 25-(OH)D level between children with ASD and the control group (WMD=-6.22

95%CI: from -12.87 to 0.44

P=0.07). Conclusion: Vitamin D deficiency may be a risk factor for ASD in children.

关键词

孤独症谱系障碍儿童维生素D病例对照研究Meta分析

Keywords

autism spectrum disorderchildrentamin Dcase-control studyMeta-analysis

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