Clinical Analysis of Kawasaki Disease Shock Syndrome in 17 Children

Li Chen; Qiu Huixian; Wu Rongzhou; Chu Maoping

doi:10.13407/j.cnki.jpp.1672-108X.2021.04.006

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Clinical Analysis of Kawasaki Disease Shock Syndrome in 17 Children

更新时间：2022-11-03

- Clinical Analysis of Kawasaki Disease Shock Syndrome in 17 Children
- Vol. 27, Issue 4, Pages: 19-23(2021)
- 作者机构：
  
  温州医科大学附属第二医院，育英儿童医院，温州医科大学心脏发育与转化医学研究所,浙江,温州,32500
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.04.006
  CLC：
- Published：2021，
  
  Published Online：10 April 2021，
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Li Chen, Qiu Huixian, Wu Rongzhou, et al. Clinical Analysis of Kawasaki Disease Shock Syndrome in 17 Children. [J]. 27(4):19-23(2021)
DOI：

Li Chen, Qiu Huixian, Wu Rongzhou, et al. Clinical Analysis of Kawasaki Disease Shock Syndrome in 17 Children. [J]. 27(4):19-23(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.04.006.

摘要

目的：探究川崎病休克综合征（Kawasaki disease shock syndrome，KDSS）患者的临床表现、早期识别、治疗方案以及预后。方法：回顾性收集17例KDSS患者的住院资料，同时为每例KDSS患者选取同时期住院的非休克川崎病患者4例作为对照组，比较其临床特征及实验室特点。结果：KDSS组患者心脏损害更加严重，KDSS组左室射血分数较对照组明显下降，氨基末端脑钠肽较对照组显著升高，并能作为有效的早期识别KDSS发生的指标；KDSS组冠脉损害发生率显著高于对照组；KDSS组患者血小板计数显著降低；KDSS组患者中性粒细胞数、CRP较对照组患者显著升高。结论：KDSS是川崎病一种严重的表现形式，其全身炎症及心脏损伤较非休克川崎病患者更为剧烈。丙种球蛋白和血管活性药物的治疗安全且有效，大多数患儿预后良好。

Abstract

Objective: To explore the clinical manifestations

early diagnosis

treatment options and prognosis of patients with Kawasaki disease shock syndrome (KDSS). Methods: The clinical data of 17 patients with KDSS were retrospectively collected. Four patients hospitalized at the same time were selected as the control group for each KDSS patient. The clinical characteristics and laboratory characteristics were compared. Results: Heart damage in the KDSS group was more serious. Compared with the control group

the left ventricular ejection fraction in the KDSS group decreased

and the amino terminal brain natriuretic peptide increased

which could be used as an effective indicator for early identification of KDSS. The incidence of coronary artery damage in the KDSS group was significantly higher than that in the control group. The platelet count in the KDSS group decreased; the number of neutrophils and C-reactive protein in the KDSS group were significantly higher than those in the control group. Conclusion: KDSS is a kind of severe form of Kawasaki disease

and its systemic inflammation and cardiac injury are more severe than those of non shock Kawasaki disease. The treatment of gamma globulin and vasoactive drugs is safe and effective

and follow-up of most patients shows good prognosis.

关键词

川崎病休克心脏损害

Keywords

Kawasaki diseaseshockcardiac injury

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