Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017

Qin Gaoyang; Yu Jialin

doi:10.13407/j.cnki.jpp.1672-108X.2021.02.005

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Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017

更新时间：2022-11-03

- Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017
- Vol. 27, Issue 2, Pages: 14-17(2021)
- 作者机构：
  
  重庆医科大学附属儿童医院,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.02.005
  CLC：
- Published：2021，
  
  Published Online：10 February 2021，
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Qin Gaoyang, Yu Jialin. Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017. [J]. 27(2):14-17(2021)
DOI：

Qin Gaoyang, Yu Jialin. Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017. [J]. 27(2):14-17(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.02.005.

摘要

目的：分析我院极低/超低出生体质量儿早发败血症（EOS）及晚发败血症（LOS）的病原分布，探讨其危险因素。方法：收集我院2012-2017年收治的极低/超低出生体质量儿临床资料，分为EOS组、LOS组及未发生败血症的对照组，回顾性分析败血症发病率、病原谱及危险因素。结果：共纳入777例极低/超低出生体质量儿，其中EOS组 106例（13.6%），LOS组 245例（31.5%）。共培养出9株EOS病原菌，大肠埃希菌占44.4%；130株LOS病原菌，肺炎克雷伯菌占39.2%。EOS患儿胎膜早破、产后心肺复苏、生后第1天机械通气概率高于对照组（P均<0.05）。LOS患儿机械通气概率高于对照组，剖宫产概率低于对照组（P均<0.05）。结论：胎膜早破、产后心肺复苏、生后第1天机械通气能增加EOS发生风险，机械通气能增加LOS发生风险。

Abstract

Objective: To analyze the pathogen distribution of early-onset sepsis (EOS) and late-onset sepsis (LOS) in very low/extremely low birth weight infants in our hospital

and explore its risk factors. Methods: The clinical data of very low/extremely low birth weight infants admitted to our hospital from 2012 to 2017 were collected

and all patients were divided into the EOS group

the LOS group and the control group (without sepsis). The incidence

pathogen spectrum and risk factors of sepsis were analyzed retrospectively. Results: A total of 777 very low/extremely low birth weight infants were included

including 106 cases (13.6%) in the EOS group and 245 cases (31.5%) in the LOS group. A total of 9 strains of EOS pathogenic bacteria were cultivated

of which Escherichia coli accounted for 44.4%; Klebsiella pneumoniae accounted for 39.2% of the 130 strains of LOS pathogenic bacteria. The rates of premature rupture of membranes

postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth in the EOS group were higher than those in the control group (P<0.05). The probability of mechanical ventilation in the LOS group was higher than that of the control group

and the probability of cesarean section was lower than that of the control group (P<0.05). Conclusion: Premature rupture of membranes

postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth can increase the risk of EOS

and mechanical ventilation can increase the risk of LOS.

关键词

极低出生体质量儿超低出生体质量儿败血症病原菌危险因素

Keywords

ery low birth weightextremely low birth weightsepsispathogensrisk factors

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