Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions

Wang Bin; Huang Shuzhen; Chen Conghua

doi:10.13407/j.cnki.jpp.1672-108X.2021.01.015

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Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions

更新时间：2022-11-03

- Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions
- Vol. 27, Issue 1, Pages: 49-52(2021)
- 作者机构：
  
  海口市妇幼保健院,海南,海口,570203
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.01.015
  CLC：
- Published：2021，
  
  Published Online：10 January 2021，
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Wang Bin, Huang Shuzhen, Chen Conghua. Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions. [J]. 27(1):49-52(2021)
DOI：

Wang Bin, Huang Shuzhen, Chen Conghua. Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions. [J]. 27(1):49-52(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.01.015.

摘要

目的：分析儿童药品不良反应（ADR）发生特点，为促进临床合理用药提供参考。方法：采用回顾性分析方法，对2011年4月至2018年12月主动上报的308例有效ADR报告进行统计分析。结果：308例ADR中，男女比例1.59:1，1~3岁年龄组发生ADR最多（51.62%）；给药途径以静脉滴注为主（93.33%）；引发ADR最多的药品种类为抗微生物药（59.20%），以头孢菌素为主（49.10%）；ADR以皮肤及其附件损害最为常见（84.07%）。结论：应注意ADR发生的相关因素，以减少ADR的发生，促进临床合理用药。

Abstract

Objective: To analyze the characteristics of pediatric adverse drug reaction (ADR)

so as to provide reference for promotion of rational drug use in clinic. Methods: Retrospective analysis was adopted

statistical analysis was conducted on 308 cases of pediatric ADR from Apr. 2011 to Dec. 2018. Results: Of the 308 cases of ADR

the ratio of male to female was 1.59∶1

the incidence of ADR was the highest in the age group from 1 to 3 years (51.62%). The main route of administration was intravenous drip (93.33%). The antimicrobial agents were the major cause of ADR in respect of the drug types (59.20%)

among which cephalosporin took the lead (49.10%). The injury of skin and its appendants appendages were the most common clinical manifestations of ADR (84.07%). Conclusion: The related factors of ADR should be monitored carefully so that ADR can be reduced and the rational drug use can be promoted.

关键词

药品不良反应儿童合理用药

Keywords

adverse drug reactionschildrenrational drug use

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