Objective: To analyze the drug sensitive characteristics of neonatal sepsis induced by Escherichia coli

so as to provide reference for the selection of antibiotics. Methods: The drug sensitivity results of 152 neonates with sepsis induced by Escherichia coli in Children’s Hospital of Chongqing Medical University from Jan. 2011 to Sept. 2018 were retrospectively analyzed. According to the time of sepsis occurrence

all patients were divided into the early onset group (<3 d) and the late onset group (≥3 d); according to production of extended-spectrum β-lactamases (ESBLs)

all patients were divided into the ESBLs (+) group and the ESBLs (-) group; according to gestational age (GA)

all patients were divided into the preterm infant group (GA<37 weeks) and the term infant group (GA ≥37 weeks). Results: The positive rate of ESBLs in the late onset group (55.6%) was not significantly different from that in the early onset group (43.4%

P>0.05). The positive rate of ESBLs in the preterm infant group (70.4%) was higher than that in the term infant group (40.8%)

and the difference was statistically significant (P<0.05). E. coli had higher resistance rate to β-lactamides

especially cephalosporins

and lower resistance rate to antibiotics containing β-lactamase inhibitors

carbapenem and aminoglycoside (4.9%~17.1%)

and there was no resistance to amikacin. The drug resistance rate of ESBLs (+) strain was higher than that of ESBLs (-) strain

with statistically significant difference (P<0.05). Conclusion: The positive rate of ESBLs in preterm infants is higher

and multi-drug resistant E. coli is increasing year by year. Antibiotics containing β-lactamase inhibitors and carbapenems should be considered as the first choice in the treatment of neonatal sepsis induced by E. Coli

especially for the E. coli of ESBLs (+).