Chloramphenicol Prednisone Liniment in the Treatment of Atopic Dermatitis in Mice

Chen Fang; Yuan Hao; Chen Shaoxiu; Chang Mingquan

doi:10.13407/j.cnki.jpp.1672-108X.2021.01.002

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Chloramphenicol Prednisone Liniment in the Treatment of Atopic Dermatitis in Mice

更新时间：2022-11-03

- Chloramphenicol Prednisone Liniment in the Treatment of Atopic Dermatitis in Mice
- Vol. 27, Issue 1, Pages: 4-7(2021)
- 作者机构：
  
  1. 十堰市太和医院,湖北,十堰,442000
  2. 湖北医药学院,湖北,十堰,442000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.01.002
  CLC：
- Published：2021，
  
  Published Online：10 January 2021，
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Chen Fang, Yuan Hao, Chen Shaoxiu, et al. Chloramphenicol Prednisone Liniment in the Treatment of Atopic Dermatitis in Mice. [J]. 27(1):4-7(2021)
DOI：

Chen Fang, Yuan Hao, Chen Shaoxiu, et al. Chloramphenicol Prednisone Liniment in the Treatment of Atopic Dermatitis in Mice. [J]. 27(1):4-7(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.2021.01.002.

摘要

目的：研究氯霉素泼尼松搽剂对小鼠急性特应性皮炎的治疗效果。方法：选取48只小鼠，分为空白组、模型组、对照组及实验低、中、高剂量组共6组，每组8只，除空白组外，其余5组小鼠均用二硝基氯苯丙酮溶液建立特应性皮炎模型，空白组、模型组给予生理盐水，对照组给予1%吡美莫司乳膏，实验组低、中、高剂量组分别给予相应浓度的氯霉素泼尼松搽剂，每天1次，7 d为1个疗程，疗程结束后24 h，以小鼠血清中IFN-γ、IL-4、IL-5、IgE值、耳肿胀度、胸腺指数、脾脏指数、皮损厚度的作为指标，评价氯霉素泼尼松搽剂对小鼠特应性皮炎的治疗效果。结果：治疗7 d后实验组小鼠血清中IL-4、IL-5和IgE水平明显低于模型组（P<0.05），IFN-γ水平明显高于模型组（P<0.05），耳肿胀度、胸腺指数、脾脏指数、皮损厚度中、高剂量组显著低于模型组（P<0.05）。结论：氯霉素泼尼松搽剂具有抗菌消炎、抗变态反应、调免疫作用，可改善特应性皮炎症状，调节Th1/Th2细胞平衡，对小鼠特应性皮炎具有显著的治疗作用，临床上可用于类似炎性皮肤病的治疗。

Abstract

Objective: To study the therapeutic effects of chloramphenicol prednisone liniment on acute atopic dermatitis in mice. Methods: Forty-eight mice were equally divided into the blank group

model group

control group and experimental groups (low dose group

medium dose group and high dose group)

with 8 cases in each group. Except for the blank group

atopic dermatitis model was established by dinitrochlorophenone solution in all the other 5 groups. The blank group and model group were given normal saline. The control group was given 1% pimecrolimus cream. The experimental groups (low dose group

medium dose group and high dose group) were given corresponding concentration of chlorine respectively

once a day

7 d for 1 course of treatment. After treatment of 24 h

the therapeutic effects of chloramphenicol prednisone liniment on atopic dermatitis in mice were evaluated by indicators of serum IFN-γ

IL-4

IL-5

IgE

ear swelling

thymus indicator

spleen indicator and skin thickness. Results: After treatment of 7 d

the levels of IL-4

IL-5 and IgE in the experimental group were significantly lower than those in the model group (P<0.05)

the levels of IFN-γ were significantly higher than those in the model group (P<0.05)

the degree of ear swelling

thymus indicator

spleen indicator and skin thickness in the medium dose group and high dose group were significantly lower than those in the model group (P<0.05). Conclusion: Chloramphenicol prednisone liniment has anti-bacterial

anti-inflammatory

anti-allergic and immune-regulating effects

which can improve the symptoms of atopic dermatitis

regulate the balance of Th1/Th2 cells

and has significant therapeutic effects on atopic dermatitis in mice. Chloramphenicol prednisone liniment can be used for the treatment of similar inflammatory skin diseases.

关键词

氯霉素泼尼松搽剂特应性皮炎疗效

Keywords

chloramphenicol prednisone linimentatopic dermatitisefficacy

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