Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology

Xu Zhili; Zhang Mingbo

doi:10.13407/j.cnki.jpp.1672-108X.2020.10.011

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Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology

更新时间：2022-11-03

- Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology
- Vol. 26, Issue 10, Pages: 32-36(2020)
- 作者机构：
  
  辽宁中医药大学药学院,辽宁,大连,116600
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.10.011
  CLC：
- Published：2020，
  
  Published Online：10 October 2020，
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Xu Zhili, Zhang Mingbo. Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology. [J]. 26(10):32-36(2020)
DOI：

Xu Zhili, Zhang Mingbo. Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology. [J]. 26(10):32-36(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.10.011.

摘要

目的：对五味子进行网络药理学研究，阐明其治疗炎性肠病的有效活性成分及潜在靶点。方法：通过生物学信息数据库预测五味子活性成分的潜在作用靶点，采用Cytoscape软件构建五味子的“成分-靶点-通路”网络模型。结果：五味子中8种成分与17个靶点具有潜在相互作用，涉及神经配体相互作用及TNF信号通路在内的多个生物过程，对炎性肠病起到治疗作用。结论：通过与炎性肠病靶点的关联筛选，结合分子对接验证，发现五味子可通过多种信号通路发挥治疗炎性肠病的作用，PTGS1（COX-1）、PTGS2（COX-2）是五味子各活性成分中作用较多的调节靶点，当归酰戈米辛O对这两个靶点的作用较强。

Abstract

Objective: To elucidate the effective active ingredients and potential targets of Schisandra chinensis in the treatment of inflammatory bowel disease based on network pharmacology. Methods: The potential targets of active ingredients in Schisandra chinensis were predicted by bioinformatics database. Cytoscape software was used to construct the “component-target-pathway” network model of Schisandra chinensis. Results: Eight components of Schisandra chinensis had potential interactions with 17 targets. Many biological processes

including nerve ligand interaction and TNF signaling pathway

played a therapeutic role in inflammatory bowel disease. Conclusion: It was found that Schisandra chinensis could alleviate inflammatory bowel disease through multiple signaling pathways. PTGS1(COX-1) and PTGS2(COX-2) were the active regulatory targets of Schisandra chinensis. Angeloylgomisin O had significant effects on these two targets.

关键词

五味子炎性肠病网络药理学

Keywords

Schisandra chinensisnflammatory bowel diseasenetwork pharmacology

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