Objective: To compare the clinical effects of drug therapy and surgical resection in children with adenoidal hypertrophy

and to guide the clinical treatment. Methods: Sixty children with adenoidal hypertrophy of grade Ⅱ and above were extracted to be divided into the observation group and the control group

with 30 cases in each group. The observation group was given drug therapy

while the control group received surgical resection. Pulmonary function

OSA-18 score and allergy symptoms questionnaire were used to evaluate children in both groups before intervention and 3 months after intervention. Results: The efficacy of two groups was equivalent

yet the observation group had more significant improvement in the discomfort symptoms

with the score of (9.25±3.26) points

while the control group was (14.82±3.32) points. The allergic symptoms of the observation group were significantly alleviated

with the total effective rate reaching 83.3%

while that in the control group was only 66.7%. The improvement of pulmonary function in the observation group was more significant

with the total effective rate reaching 90.0%

while that in the control group was 76.6%

with statistically significant difference (P<0.05). Conclusion: Drug therapy for children with adenoidal hypertrophy of grade Ⅱ and above is more suitable

especially for children under 6 years. Surgical resection of adenoids and tonsils should be considered in children with poor outcomes and confirmed by OSA-18 score as having the serious impacts on quality of life.