Comparison of Efficacy and Laboratory Indexes of L-Asparaginase and Pegaspartpase in the Treatment of Children with Acute Lymphoblastic Leukemia

Zhao Xueqin; Wang Zhengwei; Zhuang Yan; Song Aiqin

doi:10.13407/j.cnki.jpp.1672-108X.2020.10.006

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Comparison of Efficacy and Laboratory Indexes of L-Asparaginase and Pegaspartpase in the Treatment of Children with Acute Lymphoblastic Leukemia

更新时间：2022-11-03

- Comparison of Efficacy and Laboratory Indexes of L-Asparaginase and Pegaspartpase in the Treatment of Children with Acute Lymphoblastic Leukemia
- Vol. 26, Issue 10, Pages: 17-20(2020)
- 作者机构：
  
  青岛大学，山东青岛 266071，2.临沂市中医医院，山东临沂 276000，3.青岛大学附属医院,山东,青岛,266555
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.10.006
  CLC：
- Published：2020，
  
  Published Online：10 October 2020，
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Zhao Xueqin, Wang Zhengwei, Zhuang Yan, et al. Comparison of Efficacy and Laboratory Indexes of L-Asparaginase and Pegaspartpase in the Treatment of Children with Acute Lymphoblastic Leukemia. [J]. 26(10):17-20(2020)
DOI：

Zhao Xueqin, Wang Zhengwei, Zhuang Yan, et al. Comparison of Efficacy and Laboratory Indexes of L-Asparaginase and Pegaspartpase in the Treatment of Children with Acute Lymphoblastic Leukemia. [J]. 26(10):17-20(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.10.006.

摘要

目的：观察左旋门冬酰胺酶（L-Asp）及培门冬酶（PEG-Asp）两种方案治疗小儿急性淋巴细胞白血病的临床疗效。方法：选取2017年5月至2018年8月于临沂市中医医院收治的103例小儿急性淋巴细胞白血病患儿作为研究对象，回顾性分析所有患儿临床及随访资料，按照治疗药物不同分为左旋门冬酰胺酶组（L组，51例）及培门冬酶组（P组，52例），L组使用L-Asp每次6 000 U/m2，静脉注射，P组使用PEG-Asp每次2 500 U/m2，肌肉注射，比较两组患儿治疗疗效、住院时间、治疗后凝血功能障碍、肝功能情况及生理不良反应。结果：两组患儿治疗期间丙氨酸氨基转移酶水平呈上升趋势（P<0.01），P组患儿治疗期间均低于L组患儿（P<0.05）；两组患儿治疗期间白蛋白水平呈下降趋势（P<0.05）；两组患儿治疗期间总胆红素水平呈上升趋势（P<0.05）；治疗后L组患儿过敏反应及胰腺炎发生率高于P组（P<0.05）。结论：PEG-Asp治疗小儿急性淋巴细胞白血病能更快的缓解患儿病情，具有用药次数少、住院时间短、过敏反应发生率低于L组的特点，但胰腺炎发生率却高于L组，所以有关PEG-Asp的安全性还应进行进一步深入研究探讨。

Abstract

Objective: To observe the clinical efficacy of L-asparaginase (L-Asp) and pegaspargase (PEG-Asp) in the treatment of children with acute lymphoblastic leukemia. Methods: Totally 103 children with acute lymphoblastic leukemia admitted into Linyi Traditional Chinese Medicine Hospital from May 2017 to Aug. 2018 were extracted

the clinical and follow-up data of all children were analyzed retrospectively. According to different treatment drugs

all children were divided into the L-asparaginase group (group L

51 cases) and the pegaspase group (group P

52 cases). Group L was treated with L-Asp every 6

000 U/m2 intravenous injection

group P received PEG-Asp every 2

500 IU/m2 intramuscular injection. Efficacy

length of stay

coagulation dysfunction

liver function and adverse drug reactions after treatment of two groups were compared. Results: The level of alanine aminotransferase showed an increasing trend in both groups (P<0.01)

while the level of alanine aminotransferase in group P was lower than that in group L (P<0.05). The level of albumin in two groups showed a downward trend (P<0.05). The level of total bilirubin in both groups showed an upward trend (P<0.05). After treatment

the incidence of allergic reaction and pancreatitis in group L was higher than that in group P (P<0.05). Conclusion: PEG-Asp in the treatment of children with acute lymphoblastic leukemia can relieve the disease of children more quickly

with fewer times of administration

shorter length of stay and lower incidence of allergic reaction than L-Asp

but higher incidence of pancreatitis than L-Asp

and the safety of PEG-Asp should be further studied and discussed.

关键词

左旋门冬酰胺酶培门冬酶小儿急性淋巴细胞白血病临床指标

Keywords

L-asparaginasepegaspargasechildrenacute lymphoblastic leukemiaclinical indicators

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