Objective: To probe into the risk factors for prognosis of sepsis complicated with acute kidney injury in children from pediatric intensive care unit (PICU). Methods: Retrospective analysis was performed on clinical data of 80 children with sepsis admitted into PICU of our hospital from Dec. 2014 to Jan. 2020. Logistic multivariate analysis was used to analyze the risk factors for prognosis of sepsis complicated with acute kidney injury in children. Results: All children were monitored for 24 h in PICU. There were 23 cases complicated with acute kidney injury

with the incidence of 28.75% (23/80)

of which 10 cases (43.48%) died. Univariate analysis showed that there were statistically significant differences between two groups in sepsis stage

procalcitonin

arterial partial pressure of carbon dioxide

alkali residual

creatinine levels at 48 and 96 h after admission

albumin

cystatin C

urine volume

mechanical ventilation

application of vasoactive drugs and mortality (P<0.05). Multivariate Logistic regression analysis showed that septic shock

low albumin levels and high creatinine levels were risk factors for acute kidney injury in children with sepsis from PICU (OR was 3.50

2.78 and 3.51

respectively

P<0.05). Unifactorial analysis showed that mechanical ventilation

application of vasoactive drugs

sepsis stage

positive fluid balance at 72 h and lactic acid clearance rate at 6 h <10% were all correlated with death of children with sepsis complicated with acute kidney injury from PICU (P<0.05). Multivariate Logistic regression analysis showed that positive fluid balance and low lactate clearance rate were risk factors for prognosis in children with sepsis complicated with acute kidney injury from PICU (OR was 3.82 and 3.90

respectively

P<0.05). Conclusion: Children with sepsis complicated with acute kidney injury from PICU is affected by multiple factors. The development of sepsis

changes in serum albumin and cystatin C levels should be closely monitored in clinic

and timely intervention and treatment of children should be carried out to reduce the incidence and mortality of children with sepsis complicated with acute kidney injury.