Influencing Factors of Efficacy of Bosentan in the Treatment of Children with Pulmonary Arterial Hypertension

Xiang Jinxing; Chen Zhi; Yang Zhou; Wang Xun; Wang Dan; Zeng Yunhong; Xie Yonghui; Xiao Yunbin; Xiao Zhenghui

doi:10.13407/j.cnki.jpp.1672-108X.2020.09.007

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Influencing Factors of Efficacy of Bosentan in the Treatment of Children with Pulmonary Arterial Hypertension

更新时间：2022-11-03

- Influencing Factors of Efficacy of Bosentan in the Treatment of Children with Pulmonary Arterial Hypertension
- Vol. 26, Issue 9, Pages: 22-24(2020)
- 作者机构：
  
  湖南省儿童医院,湖南,长沙,410007
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.09.007
  CLC：
- Published：2020，
  
  Published Online：10 September 2020，
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Xiang Jinxing, Chen Zhi, Yang Zhou, et al. Influencing Factors of Efficacy of Bosentan in the Treatment of Children with Pulmonary Arterial Hypertension. [J]. 26(9):22-24(2020)
DOI：

Xiang Jinxing, Chen Zhi, Yang Zhou, et al. Influencing Factors of Efficacy of Bosentan in the Treatment of Children with Pulmonary Arterial Hypertension. [J]. 26(9):22-24(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.09.007.

摘要

目的：探讨波生坦治疗儿童肺动脉高压疗效的影响因素。方法：选取2013年6月至2016年6月在我院诊断为肺动脉高压且接受波生坦治疗的患儿68例，定期随访，以患儿死亡或行肺移植治疗为随访终点，收集患儿的临床资料，包括年龄、性别、身体质量指数（BMI）、病史、体格检查及治疗后血常规、心导管检查结果，对相关指标进行单因素及多因素分析，评价各种因素与波生坦治疗小儿肺动脉高压疗效的相关性。结果：患儿的年龄、水肿及纽约心脏病协会（NYHA）心功能分级、肌钙蛋白I（TnI）、血红蛋白（HGB）、总胆红素（TBIL）、肺小动脉阻力指数（PVRI）等因素与波生坦治疗儿童肺动脉高压的临床效果相关（P<0.05）。进一步多因素Logistic回归分析显示，年龄<5岁、NYHA心功能分级为Ⅲ~Ⅳ级、TBIL≥6.23 µmol/L是波生坦治疗儿童肺动脉高压疗效不佳（发生终点事件）的独立危险因素（P<0.05）。结论：影响波生坦治疗儿童肺动脉高压疗效的因素较多，临床应针对性干预。

Abstract

Objective: To explore the influencing factors of efficacy of bosentan in the treatment of children with pulmonary arterial hypertension. Methods: Totally 68 children with pulmonary arterial hypertension admitted into our hospital from Jun. 2013 to Jun. 2016 were extracted for regular follow-up. The follow-up endpoint was the death of the child or the treatment of lung transplantation. Clinical data were collected

including age

gender

body mass index (BMI)

course of disease

physical examination

blood routine and cardiac catheterization results after treatment. Univariate analysis and multivariate analysis were performed to evaluate the correlation between various factors and the therapeutic effects of bosentan on pulmonary arterial hypertension in children. Results: Age

edema

New York Heart Association (NYHA) grade of cardiac function

troponin I (TnI)

hemoglobin (HGB)

total bilirubin (TBil)

pulmonary vascular resistance index (PVRI) and other factors were correlated with the clinical effects of bosentan on pulmonary arterial hypertension in children (P<0.05). Further multivariate logistic regression analysis showed that age <5 years

NYHA grade of cardiac function from Ⅲ to Ⅳ

and TBil ≥6.23 µmol/L are independent risk factors for the poor efficacy (endpoint events) of bosentan on pulmonary arterial hypertension in children (P<0.05). Conclusion: There are many factors affecting the efficacy of bosentan in the treatment of pulmonary arterial hypertension in children

and targeted interventions should be taken in clinic.

关键词

肺动脉高压儿童波生坦影响因素

Keywords

pulmonary arterial hypertensionchildrenbosentannfluencing factors

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