Objective: To probe into the correlation between lactic acid concentration

clearance rate and disease prognosis in children with severe hand

foot and mouth disease. Methods: Totally 120 children with severe hand

foot and mouth disease admitted into the Oct. 2016 to Mar. 2018 were extracted to be divided into the non-critically ill group (n = 24)

critically ill group (n = 49) and the extremely critically ill group (n = 47). Arterial blood was collected to detect lactic acid concentration

and the clearance rate was calculated at 6 h. Correlation between lactic acid concentration

clearance rate and disease prognosis in children with severe hand

foot and mouth disease was observed. Results: The lactic acid concentration of the critically ill group and the extremely critically ill group was higher than that of the non-critically ill group

the clearance rate was lower than that of the non-critically ill group. After treatment

the fatality rate of children with lactic acid concentration from 2.0 to 3. 9 mmol/ L and ≥4. 0 mmol/ L was higher than that with lacticacid concentration <2. 0 mmol/ L (P <0. 05)

and the pediatric critical illness score (PCIS) was lower than that with lactic acid concentration <2.0 mmol/ L (P<0.05). The fatality rate and PCIS of the high lactic acid clearance group were significantly lower than that of the low lactic acid clearance group (P<0.05). Correlation analysis showed that arterial lactic acid concentration was positively correlated with PCIS (r = 0. 68

P <0. 01). lactic acid clearance rate was negatively correlated with PCIS (r = -0. 69

P <0.01).Conclusion: The higher the lactic acid concentration in children with severe hand

foot and mouth disease

the more severe the disease

the lower the lactic acid clearance rate

the worse the disease prognosis

and the higher the fatality rate. Changes of lactic acid concentration and clearance rate can be used as an important reference to judge the severity and prognosis of children with severe hand

foot and mouth disease.