Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis

Chen Jiehua; Liu Ping; Dong Yimei; Huang Li; Zhao Haixia; Wang Wenjian; Zheng Yuejie

doi:10.13407/j.cnki.jpp.1672-108X.2020.08.001

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Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis

更新时间：2022-11-03

- Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis
- Vol. 26, Issue 8, Pages: 1-3(2020)
- 作者机构：
  
  深圳市儿童医院,广东,深圳,518000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.08.001
  CLC：
- Published：2020，
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Chen Jiehua, Liu Ping, Dong Yimei, et al. Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis. [J]. 26(8):1-3(2020)
DOI：

Chen Jiehua, Liu Ping, Dong Yimei, et al. Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis. [J]. 26(8):1-3(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.08.001.

摘要

目的：了解鼻一氧化氮（nNO）检测对儿童过敏性鼻炎（AR）诊断和管理的价值。方法：选择30例经症状和过敏原特异性IgE检测确诊的AR患儿设为AR组，13例有过敏性鼻炎症状以及过敏史或过敏家族史的患儿设为可疑过敏性鼻炎（SAR）组；12例无鼻部症状、无过敏性疾病家族史的健康儿童设为正常组。使用Sunvou呼出气NO测定系统，应用鼻被动呼气+静音技术检测各组nNO水平。AR组给予鼻用激素丙酸氟替卡松鼻喷剂治疗2周后评估疗效，复查nNO，比较各组间、AR组治疗前后nNO水平。结果：三组患儿性别、年龄比较差异均无统计学意义（P均>0.05）。AR组、SAR组、正常组的nNO水平分别为（842±133）ppb、（569±44）ppb、（289±33）ppb，AR组和SAR组均高于正常组（P均<0.05）。12例（40%）AR患儿经丙酸氟替卡松鼻喷剂治疗后症状改善，治疗后nNO水平低于治疗前（P<0.05）。结论：nNO检测对AR的诊断、随访有一定的临床价值，nNO辅助诊断AR需要综合考虑鼻炎和鼻窦口通畅情况。

Abstract

Objective: To investigate value of nasal nitric oxide (nNO) as a biomarker in diagnosis and management of children with allergic rhinitis (AR). Methods: Thirty children diagnosed with symptoms and allergen-specific IgE detection were extracted as the AR group

13 children with allergic rhinitis symptoms and allergic history or allergic family history were recruited as the suspected AR (SAR) group

and 12 healthy children without nasal symptoms and allergic family history were recruited as the normal group. The Sunvou exhaled NO measurement system was adopted

the nasal passive exhalation + mute technology were used to detect the nNO level of each group. The AR group was treated with fluticasone propionate nasal spray for two weeks

and the efficacy was evaluated

the levels of nNO were detected. The levels of nNO were compared among three groups

as well as before and after treatment in the AR group. Results: There was no statistically significant difference in age and gender among three groups (P>0.05). The levels of nNO of the AR group

the SAR group and the normal group were respectively (842±133) ppb

(569±44) ppb

and (289±33) ppb

and the levels nNO of the AR group and the SAR group were higher than those of the normal group (P<0.05). The symptoms of 12 cases in the AR group were improved after treatment with fluticasone propionate nasal spray

and the levels of nNO after treatment were lower than those before treatment (P<0.05). Conclusion: nNO detection has certain clinical value for the diagnosis and follow-up of AR

and the auxiliary diagnosis of AR requires comprehensive consideration of the condition of rhinitis and paranasal sinuses.

关键词

过敏性鼻炎鼻一氧化氮儿童

Keywords

allergic rhinitisnasal nitric oxidechildren

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