Objective: To probe into the influencing factors of serum valparaiso acid (VPA) concentration in children with epilepsy. Methods: Retrospective analysis was performed on reports of 218 cases of VPA concentration monitoring in our hospital

including gender

age

total daily dose of valproate

drug combination

alanine aminotransferase

aspartate aminotransferase

plasma albumin

serum creatinine and steady-state serum concentration. Multivariate linear regression analysis was used to analyze the factors affecting the changes of VPA. Results: Multivariate linear regression analysis showed that the daily total dose was positively correlated with the serum drug concentration (P<0.05)

the total protein content was negatively correlated with the serum drug concentration (P<0.05). Different dosage forms had various influences on serum concentration

and the difference in serum concentration between valproate delayed-release tablets and syrup was statistically significant (P<0.05). Conclusion: VPA concentration is influenced by different dosage forms

dosage and total protein content of sodium valproate. There is no correlation between serum concentration and gender

age

drug combination with levetiracetam or lamotrigine

alanine aminotransferase

aspartate aminotransferase and serum creatinine