Objective: To investigate the role of clinical pharmacists in anti-infection therapy for children with severe infection. Methods: The clinical pharmacists participated into the pharmaceutical care for one child infected with carbapene-resistant Escherichia coli (CRE) and meticillin resistant Staphylococcus aureus (MRSE)

and assisted the clinicians to adjust and formulate medication regimens. Results: The clinical pharmacists applied professional knowledge

combined with the physiological and pathological conditions of children

and used pharmacokinetics/pharmacokinetics (PK/PD) parameters to optimize the anti-infection treatment regimens. The infection indexes of the child were significantly improved

and the child was discharged steadily. Conclusion: The clinical pharmacists can use the PK/PD parameters as an entry point to integrate pharmacy theory with clinical practice

assist the clinicians in developing the effective medication regimen

and become an important part of the therapeutic team.