Different Doses of Ivabradine in the Treatment of Viral Myocarditis in Children

Wang Zhijun; Cheng Yanchao; Fan Xufang; Hao Haiju

doi:10.13407/j.cnki.jpp.1672-108X.2020.07.009

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Different Doses of Ivabradine in the Treatment of Viral Myocarditis in Children

更新时间：2022-11-03

- Different Doses of Ivabradine in the Treatment of Viral Myocarditis in Children
- Vol. 26, Issue 7, Pages: 27-30(2020)
- 作者机构：
  
  郑州大学第三附属医院,河南,郑州,450052
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.07.009
  CLC：
- Published：2020，
  
  Published Online：10 July 2020，
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Wang Zhijun, Cheng Yanchao, Fan Xufang, et al. Different Doses of Ivabradine in the Treatment of Viral Myocarditis in Children. [J]. 26(7):27-30(2020)
DOI：

Wang Zhijun, Cheng Yanchao, Fan Xufang, et al. Different Doses of Ivabradine in the Treatment of Viral Myocarditis in Children. [J]. 26(7):27-30(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.07.009.

摘要

目的：探讨不同剂量伊伐布雷定治疗病毒性心肌炎（VMC）患儿的临床疗效及安全性。方法：选取2017年12月至2018年11月我院收治的病毒性心肌炎患儿84例，按就诊顺序单双号分为对照组和观察组各42例。对照组给予盐酸伊伐布雷定片2.5 mg，观察组给予盐酸伊伐布雷定片5 mg，2次/天，连续给药2周，比较两组临床疗效，观察治疗前后血清心肌肌钙蛋白I（cTnI）、心肌肌钙蛋白T（cTnT）、B型钠尿肽前体（NT-proBNP）水平及心率（HR），并记录不良反应发生情况。结果：观察组临床总有效率（90.48%）高于对照组（76.19%），差异有统计学意义P<0.05）。两组患儿治疗后cTnI、cTnT、NT-proBNP、HR水平均低于治疗前（P<0.05），且治疗后观察组cTnI、cTnT、NT-proBNP、HR水平均显著低于对照组（P<0.05）。两组不良反应均较轻微，无需停药处理，发生率比较差异无统计学意义（P>0.05）。结论：伊伐布雷定治疗VMC患儿的临床疗效显著，较大剂量的伊伐布雷定可获得更好的治疗效果，安全性可行，具有较高的临床应用价值

Abstract

Objective: To probe into the clinical efficacy and safety of different doses of ivabradine in the treatment of viral myocarditis (VMC) in children. Methods: Eighty-four children with VMC admitted to our hospital from Dec. 2017 to Nov. 2018 were selected to be divided into the control group and the observation group via the admission sequence

with 42 cases in each group. The control group was given ivabradine hydrochloride 2.5 mg

and the observation group received ivabradine hydrochloride 5 mg

twice a day for 2 weeks. The clinical efficacy of two groups was compared. The serum cardiac troponin I (cTnI)

cardiac troponin T (cTnT)

B-type natriuretic peptide precursor (NT-proBNP) levels

and heart rate (HR) were observed before and after treatment. The adverse drug reactions were recorded. Results: The total effective rate of the observation group (90.48%) was higher than that of the control group (76.19%)

with statistically significant difference (P<0.05). After treatment

the levels of cTnI

cTnT

NT-proBNP and HR in the observation group were significantly lower than those in the control group (P<0.05). Adverse drug reactions in two groups were relatively mild

no drug withdrawal was required

and the difference was not statistically significant (P>0.05). Conclusion: The clinical efficacy of ivabradine in the treatment of VMC in children is significant. Higher dose of ivaredine can achieve better therapeutic effects

which is safe and feasible

and has higher clinical application value

关键词

伊伐布雷定病毒性心肌炎心率不良反应

Keywords

abradineral myocarditisheart rateadverse drug reactions

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