Alveolar Lavage Combined with Acetylcysteine Alveolar Lavage in the Treatment of Atelectasis in Children

Li Dejun; Chen Xun; Qin Liyan; Zhou Tao; Zhou Yan; Zeng Yurong

doi:10.13407/j.cnki.jpp.1672-108X.2020.07.004

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Alveolar Lavage Combined with Acetylcysteine Alveolar Lavage in the Treatment of Atelectasis in Children

更新时间：2022-11-03

- Alveolar Lavage Combined with Acetylcysteine Alveolar Lavage in the Treatment of Atelectasis in Children
- Vol. 26, Issue 7, Pages: 10-13(2020)
- 作者机构：
  
  1. 广西梧州市工人医院,广西,梧州,543001
  2. 广西医科大学第一附属医院,广西,南宁,530021
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.07.004
  CLC：
- Published：2020，
  
  Published Online：10 July 2020，
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Li Dejun, Chen Xun, Qin Liyan, et al. Alveolar Lavage Combined with Acetylcysteine Alveolar Lavage in the Treatment of Atelectasis in Children. [J]. 26(7):10-13(2020)
DOI：

Li Dejun, Chen Xun, Qin Liyan, et al. Alveolar Lavage Combined with Acetylcysteine Alveolar Lavage in the Treatment of Atelectasis in Children. [J]. 26(7):10-13(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.07.004.

摘要

目的：观察支气管镜肺泡灌洗术联合吸入用乙酰半胱氨溶液肺泡灌洗治疗小儿肺不张的临床效果。方法：选取我院2018年1月至2019年11月收治的60例肺不张的患儿，随机分为对照组（n=30）和观察组（n=30），对照组给予支气管镜肺泡灌洗术治疗，观察组给予支气管镜肺泡灌洗术联合乙酰半胱氨酸溶液肺泡灌洗治疗，比较两组患儿临床疗效、术后肺部啰音消失时间、体温恢复时间、住院时间、需要进行肺泡灌洗的次数及影像学恢复时间、动脉血气指标[动脉血二氧化碳分压（PaCO2）、血氧分压（PaO2）、血氧饱和度（SaO2）]以及不良反应情况。结果：观察组治疗总有效率高于对照组，差异有统计学意义（P<0.05）；治疗后，观察组肺部啰音消失时间、体温恢复时间、住院时间、需要再次进行肺泡灌洗的次数及病变部位局部的影像学恢复时间等均少于对照组（P<0.05）；两组患儿PaCO2降低（P<0.05），PaO2、SaO2升高（P<0.05），观察组优于对照组（P<0.05）；治疗期间，两组患儿不良反应比较差异无统计学意义（P>0.05）。结论：支气管镜肺泡灌洗术联合乙酰半胱氨酸溶液肺泡灌洗治疗小儿肺不张疗效确切，可有效改善患儿临床症状，缩短疾病疗程，不增加不良反应

Abstract

Objective: To observe the clinical effects of alveolar lavage combined with inhalation alveolar lavage with acetylcysteine solution in the treatment of atelectasis in children. Methods: Sixty children with atelectasis admitted into our hospital from Jan. 2018 to Nov. 2019 were extracted to be randomly divided into the control group and the observation group

with 30 cases in each group. The control group was given bronchoscopic alveolar lavage

while the observation group received bronchoscopic alveolar lavage combined with inhalation alveolar lavage with acetylcysteine solution. The clinical efficacy

disappearance time of lung rales

recovery time of body temperature

length of stay

times of alveolar lavage and imaging recovery time

arterial blood gas indexes including arterial partial pressure of blood carbon dioxide (PaCO2)

partial pressure of blood oxygen (PaO2) and blood oxygen saturation (SaO2)

and adverse drug reactions of two groups were compared. Results: The total effective rate in the observation group was significantly higher than that in the control group

with statistically significant difference (P<0.05). After treatment

the disappearance time of lung rales

recovery time of body temperature

length of stay

times of alveolar lavage and imaging recovery time in the observation group were significantly shorter than those in the control group (P<0.05). PaCO2 decreased (P<0.05)

and PaO2 and SaO2 increased (P<0.05) in both groups of children

and the observation group was better than the control group (P<0.05). There were no statistically significant difference in the adverse drug reactions between two groups (P>0.05). Conclusion: The efficacy of bronchoscopic alveolar lavage combined with acetylcysteine solution alveolar lavage in the treatment of atelectasis in children is significant

which can effectively improve the clinical symptoms of children and shorten the course of disease without increasing adverse drug reactions

关键词

支气管镜肺泡灌洗乙酰半胱氨酸儿童肺不张

Keywords

bronchoscopealveolar lavageacetylcysteinechildrenatelectasis

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